Reverse transcription, also known as cDNA synthesis from an RNA template, is carried out by reverse transcriptases (RTs), an enzyme. To direct the synthesis of the first strand cDNA, reverse transcriptases (RTs) combine an RNA template with a brief primer complementary to the 3' end of the RNA.
Reverse transcriptase, an HIV enzyme, is blocked by nucleoside reverse transcriptase inhibitors (NRTIs). HIV reverse transcriptase is bound to and blocked by non-nucleoside reverse transcriptase inhibitors (NNRTIs). Reverse transcription is the process by which HIV turns RNA into DNA. HIV cannot replicate when reverse transcriptase and reverse transcription are blocked.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0728 | Ledipasvir (GS5885) | 1256388-51-8 | Ledipasvir (formerly GS5885; GS-5885; trade name Harvoni) is a novel and potent HCV NS5A polymerase inhibitor that is used for the treatment of HCV-hepatitis C virus infection. |
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V5189 | Lersivirine (UK-453061) | 473921-12-9 | Lersivirine (formerly UK-453061; UK453061) is a novel next-generation and potent non-nucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 119 nM and a unique resistance profile. |
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V54268 | M-MLV Reverse transcriptase (M-MLV RT) | 9068-38-6 | M-MLV Reverse transcriptase (M-MLV RT) is a reverse transcriptase originally developed from Moloneymurineleukemiavirus (MoMLV). |
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V1834 | MK-2048 | 869901-69-9 | MK-2048 is a potent andsecond-generation inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively. |
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V1816 | Nevirapine (BI-RG 587) | 129618-40-2 | Nevirapine (also known as NSC 641530; BI-RG 587; NSC 641530; NVP)is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) usedfor thetreatment ofHIV-1 infection and AIDS. |
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V1830 | Raltegravir (MK-0518) | 518048-05-0 | Raltegravir (formerly also known as MK-0518; trade name: Isentress) is a novel, potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM in cell-free assays, respectively. |
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V1819 | Rilpivirine (R278474; TMC278) | 500287-72-9 | Rilpivirine (formerly known as R278474; TMC278; DB08864; Edurant; Rekambys; Cabenuva), an approved HIV drug, is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that has been widely usedfor thetreatment ofHIV-1 infection. |
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V2143 | Rilpivirine HCl (TMC278; DB08864) | 700361-47-3 | Rilpivirine HCl (TMC-278;R-278474 HCl; DB-08864; Edurant; Rekambys; Cabenuva), the hydrochloride salt of Rilpivirine, is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that has been approved for thetreatment ofHIV-1 infections. |
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V1824 | Salicylanilide (WR10019) | 87-17-2 | Salicylanilide (also known as WR10019; 2-Hydroxybenzanilide) exhibits a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities. |
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V1825 | Stavudine (d4T) | 3056-17-5 | Stavudine (also known as BMY-27857, Sanilvudine, NSC 163661, and d4T) is a potent antiretroviral medication of the nucleoside analog reverse transcriptase inhibitor (NARTI) class, it is active against HIV and has been approved for preventing and treating HIV/AIDS. |
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V1820 | Telbivudine (Epavudine) | 3424-98-4 | Telbivudine (Epavudine; L-Thymidine; NV 02B; LDT 600; trade name:Tyzeka; Epavudine ) is a potent, and selective HBV (hepatitis B virus) reverse transcriptase inhibitor used primarilyin the treatment of hepatitis B infection. |
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V1811 | Tenofovir (GS 1278) | 147127-20-6 | Tenofovir (formerly also known as GS-1278; PMPA; TDF) is an approved anti-HIV drug that blocks reverse transcriptase and hepatitis B virus infections. |
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V1818 | Tenofovir Alafenamide (GS-7340) | 379270-37-8 | Tenofovir Alafenamide (formerly also known as TAF and GS-7340) is a novel prodrug of tenofovir, which is a potent reverse transcriptase inhibitor [nucleotide reverse transcriptase inhibitor (NRTIs)], it is used for the treatment ofHIV and Hepatitis B. |
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V17631 | Tenofovir alafenamide fumarate (GS-7340) | 379270-38-9 | Tenofovir Alafenamide fumarate(formerly also known as TAF and GS-7340) is a novel prodrug of tenofovir, which is a potent reverse transcriptase inhibitor [nucleotide reverse transcriptase inhibitor (NRTIs)], it is used for the treatment ofHIV and Hepatitis B. |
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V16064 | Tenofovir alafenamide hemifumarate (GS-7340) | 1392275-56-7 | Tenofovir Alafenamidehemifumarate(formerly also known as TAF and GS-7340) is a novel prodrug of tenofovir, which is a potent reverse transcriptase inhibitor [nucleotide reverse transcriptase inhibitor (NRTIs)], it is used for the treatment ofHIV and Hepatitis B. |
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V34734 | Tenofovir diphosphate (TFV-DP) | 166403-66-3 | Tenofovir diphosphate (TFV-DP) is an ATP-competitive inhibitor of DNA polymerases and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT). |
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V34735 | Tenofovir diphosphate triethylamine (TFV-DP triethylamine) | 2122333-63-3 | Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is an ATP-competitive inhibitor of DNA polymerases and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT). |
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V1812 | Tenofovir Disoproxil Fumarate (Tenofovir DF) | 202138-50-9 | Tenofovir Disoproxil Fumarate (TDF; GS-433105;Viread;Tenofovir DF), theFumarate salt of tenofovir, belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5-triphosphate and, after incorporation into DNA, by DNA chain termination. |
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V1822 | Zalcitabine (ddC; Dideoxycytidine) | 7481-89-2 | Zalcitabine (trade name Hivid) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI). |
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V1823 | Zidovudine (Azidothymidine) | 30516-87-1 | Zidovudine (also known as ZDV, Azidothymidine; Retrovir; Zidovudinum, NSC 602670) is a nucleoside analogue reverse transcriptase inhibitor (NRTI) which used to treat and prevent HIV. |
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