Telbivudine (Epavudine)

Alias: Epavudine; L-Thymidine; NV 02B; NV-02B;NV02B;NV 02 B; NV-02-B;NV02-B;LDT 600; LD-T600; LDT600; Telbivudine; Tyzeka; Epavudine
Cat No.:V1820 Purity: ≥98%
Telbivudine (Epavudine; L-Thymidine; NV 02B; LDT 600; trade name:Tyzeka; Epavudine ) is a potent, and selective HBV (hepatitis B virus) reverse transcriptase inhibitor used primarilyin the treatment of hepatitis B infection.
Telbivudine (Epavudine) Chemical Structure CAS No.: 3424-98-4
Product category: Reverse Transcriptase
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
5mg
10mg
25mg
50mg
100mg
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500mg
Other Sizes

Other Forms of Telbivudine (Epavudine):

  • Granisetron-d3
  • Telbivudine-d4
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Telbivudine (Epavudine; L-Thymidine; NV 02B; LDT 600; trade name:Tyzeka; Epavudine ) is a potent, and selective HBV (hepatitis B virus) reverse transcriptase inhibitor used primarily in the treatment of hepatitis B infection. It is an antiviral drug approved for the treatment of hepatitis B infection. Telbivudine is phosphorylated by intracellular thymidine kinases to the active triphosphate form, which has an intracellular half-life of 14 hours. Telbivudine 5′-triphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate, dTTP.

Biological Activity I Assay Protocols (From Reference)
ln Vitro
Telbivudine prevents vulnerable cells from dying by reversing the deregulation of BIRC3 brought on by B19V, interfering with the apoptotic process[2].
ln Vivo
Telbivudine is an antiviral drug used in the treatment of hepatitis B infection. It is marketed by Swiss pharmaceutical company Novartis under the trade names Sebivo (Europe) and Tyzeka (United States). Clinical trials have shown it to be significantly more effective than lamivudine or adefovir, and less likely to cause resistance. Telbivudine is a synthetic thymidine nucleoside analogue, it is the L-isomer of thymidine. It is taken once daily. Telbivudine is a potent antiviral that provides effective and sustained viral suppression in patients with compensated CHB. In clinical trials, treatment outcomes were improved significantly more with telbivudine 600 mg once daily than with lamivudine 100 mg or adefovir 10 mg once daily, and telbivudine-treated patients had significantly less viral resistance than lamivudine-treated patients. Telbivudine is associated with a medium genetic barrier to resistance and, as patients with undetectable HBV DNA levels have significantly improved outcomes, it is recommended that HBV DNA levels are monitored at week 24 (and 6 monthly thereafter), with the addition of a nucleoside/nucleotide analogue without cross resistance (such as adefovir dipivoxil) if viraemia is present to reduce the risk of resistance (Roadmap concept). Telbivudine was generally well tolerated in clinical trials for periods of up to 4 years, and has a similar tolerability profile to that of lamivudine.
Animal Protocol


References
[1]. Kim JW, et al. Telbivudine: a novel nucleoside analog for chronic hepatitis B. Ann Pharmacother. 2006;40(3):472-478.
[2]. Zobel T, et al. Telbivudine Reduces Parvovirus B19-Induced Apoptosis in Circulating Angiogenic Cells. Viruses. 2019;11(3):227. Published 2019 Mar 6.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C10H14N2O5
Molecular Weight
242.23
CAS #
3424-98-4
SMILES
O1C([H])(C([H])([H])O[H])C([H])(C([H])([H])C1([H])N1C(N([H])C(C(C([H])([H])[H])=C1[H])=O)=O)O[H]
InChi Key
IQFYYKKMVGJFEH-CSMHCCOUSA-N
InChi Code
InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1
Chemical Name
1-((2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Synonyms
Epavudine; L-Thymidine; NV 02B; NV-02B;NV02B;NV 02 B; NV-02-B;NV02-B;LDT 600; LD-T600; LDT600; Telbivudine; Tyzeka; Epavudine
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: 48 mg/mL (198.2 mM)
Water:48 mg/mL (198.2 mM)
Ethanol: 2 mg/mL warmed (8.3 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 4.1283 mL 20.6415 mL 41.2831 mL
5 mM 0.8257 mL 4.1283 mL 8.2566 mL
10 mM 0.4128 mL 2.0642 mL 4.1283 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

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