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    Ibutilide Fumarate (U70226E)
    Ibutilide Fumarate (U70226E)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1663
    CAS #: 122647-32-9Purity ≥98%

    Description: Ibutilide Fumarate (also known as U-70226E) belongs to the Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells. Ibutilide Fumarate is a sodium channel protein inhibitor and methanesulfonanilide anti-arrhythmic agent that prolongs myocardial action potential duration mostly by activation of slow inward sodium current.

    References: Chin Med J (Engl). 2012 Aug;125(15):2701-7.

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    Molecular Weight (MW)885.23 
    Formula(C20H36N2O3S)2.C4H4O4 
    CAS No.122647-32-9 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 89 mg/mL (100.5 mM)
    Water: 89 mg/mL (100.5 mM)
    Ethanol: 89 mg/mL (100.5 mM)
    Other info

    Chemical Name: N-[4-[4-[ethyl(heptyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide

    InChi Key: ALOBUEHUHMBRLE-UHFFFAOYSA-N

    InChi Code: InChI=1S/C20H36N2O3S/c1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19(15-13-18)21-26(3,24)25/h12-15,20-21,23H,4-11,16-17H2,1-3H3

    SMILES Code: CS(=O)(NC1=CC=C(C(O)CCCN(CC)CCCCCCC)C=C1)=O

    SynonymsU70226E; U 70226E; U70226 E; U 70226 E; U-70226-E; U-70226E 


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    In Vitro

    In vitro activity: Ibutilide protected against H2O2-induced cardiomyocytes injury through inhibiting endoplasmic reticulum and mitochondrial stress pathways.

    In VivoIbutilide significantly decreased defibrillation threshold through the reduction of activation pattern complexity during ventricular fibrillation in canine hearts. 
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    Formulation & Dosage
    References

    Chin Med J (Engl). 125, 2701-2707. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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