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      Camostat Mesilate (FOY305)
      Camostat Mesilate (FOY305)

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      This product is for research use only, not for human use. We do not sell to patients.
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      InvivoChem Cat #: V1660
      CAS #: 59721-29-8Purity ≥98%

      Description: Camostat mesylate (also known as FOY-305; FOY-S980) is a potent and orally active trypsin-like protease inhibitor, it act by inhibiting airway epithelial sodium channel (ENaC) function with IC50 of 50 nM,  and is less potent to trpsin, prostasin and matriptase. Camostat (30 μM) prolongs attenuation of ENaC function in human airway epithelial cell models that is reversible upon the addition of excess trypsin. Camostat mesilate (500 mM) inhibits generation of TGF-beta by suppressing plasmin activity and reduces the activity of TGF-beta, which blocks in vitro activation of HSCs.

      References: J Pharmacol Exp Ther. 2009 May;329(2):764-74; Gastroenterology. 2001 Jun;120(7):1784-800.

      Related CAS #: 59721-29-8 (mesylate)   59721-28-7 (free base) 

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      Molecular Weight (MW)494.52 
      FormulaC20H22N4O5.CH4O3S 
      CAS No.59721-29-8 
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 99 mg/mL (200.2 mM) 
      Water: 10 mg/mL (20.2 mM) 
      Ethanol: <1 mg/mL
      Other info

      Chemical Name: 4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate methanesulfonate

      InChi Key: FSEKIHNIDBATFG-UHFFFAOYSA-N

      InChi Code: InChI=1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)

      SMILES Code: O=C(OCC(N(C)C)=O)CC1=CC=C(OC(C2=CC=C(NC(N)=N)C=C2)=O)C=C1.CS(=O)(O)=O

      SynonymsFOY-305; FOY 305; FOY305; Camostat Mesilate; Camostat Mesylate


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      In Vitro

      In vitro activity: Camostat (30 μM) prolongs attenuation of ENaC function in human airway epithelial cell models that is reversible upon the addition of excess trypsin. Camostat mesilate (500 mM) inhibits generation of TGF-beta by suppressing plasmin activity and reduces the activity of TGF-beta, which blocks in vitro activation of HSCs. Camostat mesilate (20 mM) combined with insulin results a significant hypoglycemic effect following large intestinal administration. Camostat mesilate (20 mM) is effective in reducing insulin degradation in both small and large intestinal homogenates of rats. Camostat mesilate (2 mM) inhibits MCP-1 and TNF- production in activated rat monocytes. Camostat mesilate (2 mM) inhibits proliferation and MCP-1 production of cultured rat PSCs.

      In VivoCamostat (100 μg/kg i.t.) induces a potent and prolonged attenuation of ENaC activity in the guinea pig trachea. Camostat mesilate (1-2 mg/g of diet) markedly attenuats an increase in hepatic plasmin and TGF-beta levels, HSC activation, and hepatic fibrosis without apparent systemic or local side effects in porcine serum–treated rats. Camostat mesilate (1 mg/g) prevents pancreatic atrophy and improves pancreatic exocrine function of rat chronic pancreatitis induced by DBTC. Camostat mesilate (1 mg/g) inhibits chronic inflammation and pancreatic fibrosis induced by DBTC. Camostat mesilate (1 mg/g) inhibits the development of pancreatic fibrosis and PSCs activation in the pancreas induced by DBTC. Camostat mesilate (1 mg/g) suppresses monocytes infiltration and inhibits MCP-1 expression both in serum and in pancreatic tissue. Camostat mesilate (100 mg/kg) significantly increases the body weight and pancreatic wet weight, and it significantly inhibits inflammatory changes and fibrosis of the pancreas through the suppression of gene expressions of PAP, p8, and cytokines in rat chronic pancreatitis. 
      Animal modelMale Wistar rats 
      Formulation & DosageDissolved in saline;  2 mg/kg; take with diet
      References

      J Pharmacol Exp Ther. 2009 May;329(2):764-74; Gastroenterology. 2001 Jun;120(7):1784-800. 

      These protocols are for reference only. InvivoChem does not independently validate these methods.

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