Cesium chloride (CsCl) inhibits the effects of acrylamide on membrane potential, intracellular calcium levels, and the expressions of NOS, ET-1, and VEGF, which are all upregulated[3].

Cesium chloride (12 mg/100 g body weight, daily for 30 days; ip; male Wistar rats–BOO model) may considerably reduce the impact of XJT (traditional Chinese medicine) on bladder weight, urodynamics, and oxidative stress in addition to the expression of these potassium channels[1].

Absorption, Distribution and Excretion
102 healthy volunteers ingested real and simulated 134CsCl particle sediment solutions. The average radioactive uptake of the sediments over one week was 3%, ranging from 0-9%. Distribution-excretion patterns of 137Cs in guinea pigs were obtained over 100 days after administration via three different routes. Three groups of guinea pigs, 20 in each group, were used. Animals were administered Caesium chloride solutions containing the 137Cs tracer via inhalation, oral administration, and intraperitoneal injection, respectively. Urine and feces were collected daily until sacrifice, and tissue distribution patterns were determined post-mortem. All measurements were performed using gamma counting with a NaI(Tl) detector. Due to the high solubility of Caesium chloride, it was rapidly absorbed from the lungs, digestive tract, and peritoneum. The highest concentration of 137Cs was observed in skeletal muscle after day one. Its retention in muscle can be approximated by a single exponential function, with an average biological half-life of 10 days. Concentrations in other tissues are not significantly different from those in muscle. The concentration of ¹³⁷Cs in total excrement follows an exponential pattern, comprising both rapid and slow declines. The average urine-to-feces ratio is 2.8. Over 95% of ¹³⁷Cs is excreted within 32 days; at this point, approximately 65% of the remaining radioactive material is located in skeletal muscle. The absorption of CsCl, SrCl₂, BaCl₂, and CeCl₃ deposited on the nasal mucosa into the systemic circulation was studied in Syrian hamsters and compared with gastrointestinal absorption. Over 50% of Caesium, strontium, and barium were absorbed directly via the nasal mucosa, while the absorption rate of cerium was less than 4%. For all isotopes, nasal absorption was approximately equal to or greater than gastrointestinal absorption within the first 4 hours after administration. This study highlights the importance of direct nasal absorption of deposited substances in inhalation toxicity assessments, especially when nasopharyngeal deposition is dominant in readily soluble aerosols with a median aerodynamic diameter greater than 5 micrometers.

Non-Human Toxicity Values
Rat intraperitoneal injection LD50 1.5 g/kg

[1]. A Chinese Medicine Formula "Xian-Jia-Tang" for Treating Bladder Outlet Obstruction by Improving Urodynamics and Inhibiting Oxidative Stress through Potassium Channels. Evid Based Complement Alternat Med. 2017;2017:8147258.

[2]. Alloxan decreases intracellular potassium content of the isolated frog skin epithelium. Comp Biochem Physiol C Toxicol Pharmacol. 2001;130(1):19-27.

[3]. Mitochondrial ROS-K+ channel signaling pathway regulated secretion of human pulmonary artery endothelial cells. Free Radic Res. 2012;46(12):1437-1445.

[4]. Cesium-induced QT-interval prolongation in an adolescent. Pharmacotherapy. 2008;28(8):1059-1065.

Caesium chloride is the inorganic chloride of Caesium; each Caesium ion is coordinated to eight chloride ions. It is a phase-transfer catalyst and a vasoconstrictor. It is both an inorganic chloride and an inorganic Caesium salt.
See also: Caesium cations (containing the active moiety)...See more...

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Mechanism of action
...Potassium channel blocker...capable of producing early after-depolarization (EAD) and polymorphic ventricular arrhythmias similar to torsades de pointes.
Caesium ions block potassium channels in biological membranes in a voltage-dependent manner. For example, exogenous Caesium blocks inward currents while having little effect on outward currents. Therefore, it produces a characteristic N-shaped current-voltage relationship. /Caesium ion/

CLCS

168.36

167.874

7647-17-8

24293

White to off-white solid powder

3.983

1290 °C

645 °C(lit.)

1303°C

1.6418

0

1

0

2

2

0

AIYUHDOJVYHVIT-UHFFFAOYSA-M

InChI=1S/ClH.Cs/h1H;/q;+1/p-1

cesium;chloride

2934.99.9001

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.

Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples

Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.

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Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)
*Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution.
Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline)
Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil)
Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals).

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Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)]
*Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.
Injection Formulation 5: 2-Hydroxypropyl-β-cyclodextrin : Saline = 50 : 50 (i.e. 500 μL 2-Hydroxypropyl-β-cyclodextrin → 500 μL Saline)
Injection Formulation 6: DMSO : PEG300 : castor oil : Saline = 5 : 10 : 20 : 65 (i.e. 50 μL DMSO → 100 μLPEG300 → 200 μL castor oil → 650 μL Saline)
Injection Formulation 7: Ethanol : Cremophor : Saline = 10： 10 : 80 (i.e. 100 μL Ethanol → 100 μL Cremophor → 800 μL Saline)
Injection Formulation 8: Dissolve in Cremophor/Ethanol (50 : 50), then diluted by Saline
Injection Formulation 9: EtOH : Corn oil = 10 : 90 (i.e. 100 μL EtOH → 900 μL Corn oil)
Injection Formulation 10: EtOH : PEG300：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL EtOH → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline)

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Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium)
Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose
Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals).

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Oral Formulation 3: Dissolved in PEG400
Oral Formulation 4: Suspend in 0.2% Carboxymethyl cellulose
Oral Formulation 5: Dissolve in 0.25% Tween 80 and 0.5% Carboxymethyl cellulose
Oral Formulation 6: Mixing with food powders

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Note: Please be aware that the above formulations are for reference only. InvivoChem strongly recommends customers to read literature methods/protocols carefully before determining which formulation you should use for in vivo studies, as different compounds have different solubility properties and have to be formulated differently.

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 (Please use freshly prepared in vivo formulations for optimal results.)