Nicotinic acetylcholine receptors, or nAChRs, are proteins on neurons that signal when a chemical stimulus causes muscles to contract. On the presynaptic and postsynaptic sides of the neuromuscular junction, as well as in the plasma membranes of some neurons, they are cholinergic receptors that create ligand-gated ion channels. The most extensively researched ionotropic receptors are those for nicotinic acetylcholine. The neurotransmitter acetylcholine (ACh) binds to the nAChR, just like it does with the other type of acetylcholine receptor, the muscarinic acetylcholine receptor (mAChR). Nicotinic receptors can be opened by both acetylcholine and nicotine, hence the name "nicotinic," just as muscarinic receptors are so named because they are also activated by muscarine.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V81786 | α-Conotoxin Bt1.8 | α-Conotoxin Bt1.8 is a potent inhibitor of α6/α3β2β3 and α3β2 nAChRs, with IC50s of 2.1 nM and 9.4 nM for rat α6/α3β2β3 and α3β2, respectively. | |
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V70743 | α-Conotoxin BuIA | 846539-62-6 | α-Conotoxin BuIA is a paralytic peptide neurotoxin and competitive nAChR antagonist (inhibitor) with IC50 of 0.258 nM (α6/α3β2), 1.54 nM (α6/α3β4), 5.72 nM (α3β2). |
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V70764 | α-Conotoxin EI | 170663-33-9 | α-Conotoxin EI is a selective nicotine acetylcholine α1β1γδ receptor (nAChR) antagonist (IC50=187 nM) and α3β4 receptor blocker/inhibitor. |
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V81787 | α-Conotoxin EIIB (Alpha-conotoxin EIIB) | Alpha-conotoxin EIIB (Alpha-conotoxin EIIB) is a toxin peptide obtained from conus ermineus toxin and can bind to nAChR (Ki=2.2 nM). | |
|
V70774 | α-Conotoxin GI | 76862-65-2 | α-Conotoxin GI has high affinity for nAChR. |
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V70746 | α-Conotoxin GIC | 757236-92-3 | α-Conotoxin GIC is a potent and specific α3β2 nicotinic antagonist (inhibitor) with IC50 of 1.1 nM. |
|
V70760 | α-Conotoxin GID | 547741-78-6 | α-Conotoxin GID is a paralytic peptide neurotoxin and a selective antagonist of nAChR with IC50 of 5 nM (α7), 3 nM (α3β2), and 150 nM (α4β2). |
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V81788 | α-Conotoxin LtIA | α-Conotoxin LtIA is an α3β2 nAChR blocker (IC50=9.8 nM) obtained from the venom of Conus litteratus. | |
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V70533 | α-Conotoxin MI | 88217-10-1 | α-Conotoxin MI is a selective inhibitor of mAChR and α1β1γδ nAChR but has no effect on nicotine-stimulated dopamine release. |
|
V70710 | α-Conotoxin MII (α-CTxMII) | 175735-93-0 | α-Conotoxin MII (α-CTxMII) is extracted from the sea snail Conus magus and effectively inhibits the α3β2 subunit of the nAChR receptor, with IC50 of 0.5 nM. |
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V81789 | α-Conotoxin MII TFA (α-CTxMII TFA) | α-Conotoxin MII TFA (α-CTxMII TFA) is extracted from the sea snail Conus magus and effectively inhibits the α3β2 subunit of the nAChR receptor, with IC50 of 0.5 nM. | |
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V70732 | α-Conotoxin MrIC | 1417816-41-1 | α-Conotoxin MrIC is an α7nAChR biased agonist. |
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V70749 | α-Conotoxin PeIA | 866876-88-2 | α-Conotoxin PeIA is an analgesic α-conotoxin. |
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V70765 | α-Conotoxin PIA (α-Conotoxin PIA) | 669050-68-4 | α-Conotoxin PIA is a nicotinic acetylcholine receptor (nAChR) antagonist that targets nAChRs containing α6 and α3 subunits. |
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V73422 | α-Conotoxin PIA TFA (α-Conotoxin PIA trifluoroacetate) | α-Conotoxin PIA TFA is a nicotinic acetylcholine receptor (nAChR) antagonist that targets nAChRs containing α6 and α3 subunits. | |
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V70768 | α-Conotoxin PnIA (α-Conotoxin PnIA) | 705300-84-1 | α-Conotoxin PnIA is a potent and specific mammalian α7nAChR antagonist (inhibitor) with potential for studying neurological diseases such as neuropathic pain and AD/Alzheimer's disease. |
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V73417 | α-Conotoxin PnIA TFA (α-Conotoxin PnIA trifluoroacetate) | α-Conotoxin PnIA TFA is a potent and specific mammalian α7nAChR antagonist (inhibitor) with potential for studying neurological diseases such as neuropathic pain and AD/Alzheimer's disease. | |
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V70744 | α-Conotoxin RgIA (α-RgIA) | 876728-23-3 | α-Conotoxin RgIA (α-RgIA) is a specific α9α10 nAChR antagonist. |
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V70755 | α-Conotoxin S IA | 135190-31-7 | α-Conotoxin SIA is a selective nicotinic acetylcholine receptor (nAChR) antagonist (inhibitor) with high affinity for muscle nAChR. |
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V70761 | α-Conotoxin TxID | 1496617-64-1 | α-Conotoxin TxID is a potent α3β4 nAChR antagonist (inhibitor) with IC50 of 12.5 nM. |
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