The neurotransmitter glutamate activates the iGluR (ionotropic glutamate receptor), an ion channel that is ligand-gated. The central ion channel pore is formed by four large subunits of the integral membrane protein iGluR. All known glutamate receptor subunits, including the AMPA, kainate, NMDA, and receptors, share a similar amino acid sequence.
The primary charge carriers during basal transmission are AMPA receptors, which allow an influx of sodium ions to depolarize the postsynaptic membrane. Magnesium ions block NMDA receptors, which only allow ion flux after a previous depolarization. They can now serve as coincidence detectors for synaptic plasticity because of this. NMDA receptors allow calcium to enter the body, which permanently changes how strongly synaptic transmission is carried out.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70396 | Osavampator (TAK-653) | 1358751-06-0 | Osavampator (TAK-653) is a novel AMPA receptor-PAM (positive allosteric modulator). |
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V70460 | p-fin4 | 2883747-74-6 | p-fin4 is a bioactive peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with Ki of 0.4 μM. |
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V81027 | p3Ysh-3 | p3Ysh-3 is a bioactive peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with Ki of 1.09 μM. | |
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V70454 | PDZ1 Domain inhibitor peptide | 1315378-73-4 | PDZ1 Domain inhibitor peptide is a cyclic peptide that binds to the β-Ala lactam side chain linker and targets the PDZ1 domain of PSD-95. |
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V81063 | PDZ1 Domain inhibitor peptide TFA | PDZ1 Domain inhibitor peptide TFA is a cyclic peptide that binds to the β-Ala lactam side chain linker and targets the PDZ1 domain of PSD-95. | |
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V76650 | PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) | PEAQX (NVP-AAM077) tetrasodium hydrate is a specific, orally bioavailable NMDA antagonist (inhibitor) with IC50s of 270 nM and 29600 nM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. | |
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V32952 | PEPA | 141286-78-4 | PEPA is an allosteric modulator of AMPAR and can bind to the LBDs domain of GluA2o/GluA3o. |
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V27543 | PhTx-74 diHCl | 1227301-51-0 | PhTx-74 HCl (Philanthotoxin 74;PhTx 74;PhTx74),the dihydrochloride salt ofPhTx-74, isananalogue of philanthotoxin-4,3,3 which is anaturally-occurring wasp venom toxin. |
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V70414 | Plazinemdor (CAD-9303) | 2378285-59-5 | Plazinemdor is a PAM (positive allosteric modulator) of N-methyl-D-aspartate (NMDA) receptors utilized in the research of psychiatric, neurological, neurodevelopmental disorders and neurological diseases. |
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V70469 | Pregnanolone sulfate (pyridinium) | 124107-39-7 | Pregnanolone sulfate pyridinium is an endogenous neurosteroid that can inhibit NMDA receptors and has neuro-protective (neuro-protection) effects. |
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V2968 | QNZ46 | 1237744-13-6 | QNZ46 is a novelnon-competitive andNR2C/NR2D-selective NMDA receptor antagonist with IC50 values of 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively. |
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V70445 | Risevistinel (NYX-783) | 2591344-26-0 | Risevistinel (NYX-783) is a PAM (positive allosteric modulator) of the N-methyl-D-aspartate (NMDA) receptor. |
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V70478 | Ro 04-5595 hydrochloride | 64047-73-0 | Ro 04-5595 HCl is a GluN2B-selective NMDA receptor blocker (antagonist) (Ki= 31 nM). |
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V70487 | SDZ 220-040 | 174575-40-7 | SDZ 220-040 is a competitive mammalian NMDA receptor blocker (antagonist). |
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V32239 | SDZ 220-581 Ammonium salt | 179411-94-0 | SDZ 220-581 Ammonium salt (SDZ-220581; SDZ220581) is a novel and competitive antagonist of NMDA glutamate receptor subtype (pKi= 7.7) with the potential to be used forParkinsons disease. |
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V32240 | SDZ 220-581 hydrochloride | 179411-93-9 | SDZ 220-581 hydrochloride (SDZ220581; SDZ-220581) is a novel and competitive antagonist of NMDA glutamate receptor subtype (pKi= 7.7) with the potential to be used forParkinsons disease. |
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V18801 | SDZ-220-581 | 174575-17-8 | SDZ-220-581 (SDZ-220581; SDZ220581) is a novel and potent competitive antagonist of NMDA glutamate receptor subtype(pKi= 7.7) with the potential to be used forParkinsons disease. |
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V38653 | Sepimostat | 103926-64-3 | Desription: Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. |
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V2439 | Sepimostate mesilate | 103926-82-5 | Sepimostate mesilate(also known as FUT-187orTO 187) is aninhibitor used in therapy of pancreatitis, it inhibits the Ifenprodil binding with a Ki value of 27.7 µM. |
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V4073 | Sunifiram (DM-235) | 314728-85-3 | Sunifiram (also known as DM-235), a piperazine derived ampakine-like drug, has potent nootropic effects in animal studies with significantly higher potency than piracetam. |
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