The neurotransmitter glutamate activates the iGluR (ionotropic glutamate receptor), an ion channel that is ligand-gated. The central ion channel pore is formed by four large subunits of the integral membrane protein iGluR. All known glutamate receptor subunits, including the AMPA, kainate, NMDA, and receptors, share a similar amino acid sequence.
The primary charge carriers during basal transmission are AMPA receptors, which allow an influx of sodium ions to depolarize the postsynaptic membrane. Magnesium ions block NMDA receptors, which only allow ion flux after a previous depolarization. They can now serve as coincidence detectors for synaptic plasticity because of this. NMDA receptors allow calcium to enter the body, which permanently changes how strongly synaptic transmission is carried out.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70448 | Decanoic acid-d19 (decanoic acid d19) | 88170-22-3 | Decanoic acid-d199 is the deuterated form of Decanoic acid. |
|
V70490 | Decanoic acid-d2 (decanoic acid d2) | 62716-49-8 | Decanoic acid-d2 is the deuterated form of Decanoic acid. |
|
V70422 | Decanoic acid-d3 (decanoic acid d3) | 102611-15-4 | Decanoic acid-d3 is the deuterated form of Decanoic acid. |
|
V70458 | DL-AP7 (2-APH; 2-Amino-7-phosphonoheptanoic acid) | 85797-13-3 | DL-AP7 is a competitive NMDA antagonist and anticonvulsant (antiepileptic/antiseizure). |
|
V20240 | DQP-1105 | 380560-89-4 | DQP-1105 (DQP1105) is a novel, potent, non-competitive and negative allosteric modulator of the GluN2C/D NMDA receptor with potential to be used for Neuroscience applications. |
|
V70447 | DQP-26 | 1449373-99-2 | DQP-26 is a potent NAM (negative allosteric modulator) of NMDAR with IC50s of 0.77 μM and 0.44 μM for GluN2C and GluN2D, respectively. |
|
V2847 | Eliprodil | 119431-25-3 | Eliprodil (formerly known as SL-820715) is a non-competitive NR2B-NMDA receptor antagonist with IC50 value of 1 uM, it is less potent for NR2A- and NR2C-containing receptors with IC50 > 100 uM. |
|
V70482 | Ensaculin free base (KA-672; Anseculin) | 155773-59-4 | Ensaculin free base (KA-672) is an NMDA antagonist (inhibitor) with high affinity for serotonergic 5-HT1A and 5-HT7 receptors, adrenergic α1, and dopaminergic D2 and D3 receptors. |
|
V3241 | Farampator (CX-691, Org24448) | 211735-76-1 | Farampator (also known as CX-691 or Org24448) is a positive and allosteric modulator of theAMPA (alpha-amino-3-hydroxy-5-methyl-4-isoazolepropionic acid) receptor. |
|
V70408 | Felbamate-d4 (felbamate d4) | 106817-52-1 | Felbamate-d4 is the deuterium labelled form of Felbamate. |
|
V70450 | Felbamate-d5 (Felbamyl-d5; Felbatol-d5; Taloxa-d5) | 1191888-51-3 | Felbamate-d5 is the deuterium labelled form of Felbamate. |
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V70462 | Fluoroethylnormemantine | 1639210-26-6 | Fluoroethylnormemantine is an analogue of Memantine and an antagonist of N-methyl-D-aspartate (NMDA) receptors. |
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V70423 | Fluoroethylnormemantine hydrochloride | 1639210-25-5 | Fluoroethylnormemantine HCl is an analogue of Memantine and an antagonist of N-methyl-D-aspartate (NMDA) receptors. |
|
V70456 | Flupirtine-d4 hydrochloride (D 9998-d4 hydrochloride) | 1324717-75-0 | Flupirtine-d4 (D 9998-d4) HCl is the deuterated form of Flupirtine. |
|
V70459 | Gavestinel (GV 150526) | 153436-22-7 | Gavestinel (GV 150526) is a potent and selective NMDA receptor glycine site antagonist. |
|
V70491 | GluN2B receptor modulator-1 | 2222010-71-9 | GluN2B receptor modulator-1 is a selective negative allosteric modulator (NAM) of GluN2B with IC50 of 31 nM. |
|
V76971 | GluN2B-NMDAR antagonist-1 | GluN2B-NMDAR antagonist-1 is an orally bioactive GluN2B-NMDAR antagonist. | |
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V4907 | GNE-8324 | 1698901-76-6 | GNE-8324 (GNE8324) is a novel, potent and selective PAM (Positive Allosteric Modulators) of NMDA receptor. |
|
V70409 | GNE-9278 | 2315311-83-0 | GNE-9278 is a selective PAM (positive allosteric modulator) of NMDAR that acts on the GluN1 transmembrane domain (TMD). |
|
V70385 | GYKI 52466 hydrochloride | 192065-56-8 | GYKI 52466 HCl is an orally bioactive, selective and noncompetitive AMPA/Kainate receptor antagonist (inhibitor) with IC50s of 7.5 and 11 μM respectively. |
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