The neurotransmitter glutamate activates the iGluR (ionotropic glutamate receptor), an ion channel that is ligand-gated. The central ion channel pore is formed by four large subunits of the integral membrane protein iGluR. All known glutamate receptor subunits, including the AMPA, kainate, NMDA, and receptors, share a similar amino acid sequence.
The primary charge carriers during basal transmission are AMPA receptors, which allow an influx of sodium ions to depolarize the postsynaptic membrane. Magnesium ions block NMDA receptors, which only allow ion flux after a previous depolarization. They can now serve as coincidence detectors for synaptic plasticity because of this. NMDA receptors allow calcium to enter the body, which permanently changes how strongly synaptic transmission is carried out.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V3755 | NBQX | 118876-58-7 | NBQX (also known asFG9202) is a novel and potentantagonist ofaminomethylphosphonic acid receptor (AMPAR)with IC50of 0.7 ± 0.1 μM. |
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V16605 | NBQX Disodium | 479347-86-9 | NBQX (also known asFG9202) is a novel, potentselective and competitive antagonist ofaminomethylphosphonic acid receptor (AMPAR)with IC50of 0.7 ± 0.1 μM. |
|
V70397 | Nelonemdaz potassium (Salfaprodil; Neu2000 potassium) | 916214-57-8 | Nelonemdaz (Salfaprodil) potassium is an NR2B-selective and noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and a free radical scavenger. |
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V70486 | Nevadistinel (NYX-458; NYX-3054) | 2181816-92-0 | Nevadistinel (NYX-458; NYX-3054) is a PAM (positive allosteric modulator) of the N-methyl-D-aspartate (NMDA) receptor. |
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V70431 | NMDA receptor antagonist 2 | 875898-41-2 | NMDA receptor antagonist 2 is a potent, oral NR2B isoform-selective NMDA antagonist (inhibitor) with IC50 and Ki of 1.0 nM and 0.88 nM, respectively. |
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V78903 | NMDA receptor antagonist 6 | NMDA receptor antagonist 6 (compound 13b) is an antagonist of the NMDA receptor that targets the glycine binding site. | |
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V79449 | NMDA receptor antagonist 7 | NMDA receptor antagonist 7 (Compound (S)-10a) is a GluN2B subunit-selective NMDA receptor antagonist (inhibitor) with a Ki of 93 nM and IC50 of 72 nM. | |
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V79450 | NMDA receptor antagonist 8 | NMDA receptor antagonist 8 (Compound (R)-10a) is a GluN2B subunit-selective NMDA receptor antagonist (inhibitor) with a Ki of 265 nM and IC50 of 62 nM. | |
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V70435 | NMDA receptor antagonist-3 | 2762181-52-0 | NMDA receptor antagonist-3 is an NMDA receptor antagonist (inhibitor) with significant recovery rate (40.0%, 100 μM) and safety and toxicological characteristics in SH-SY5Y and human adipose mesenchymal stem cells. |
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V69803 | NMDAR/TRPM4-IN-2 | 2243506-33-2 | NMDAR/TRPM4-IN-2 (compound 8) is a potent inhibitor of the NMDAR/TRPM4 interaction interface. |
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V26594 | Noopept | 157115-85-0 | Omberacetam (GVS-111) is a bioactive peptide available as a dietary supplement. |
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V70440 | NPEC-caged-(S)-AMPA | 1257323-84-4 | NPEC-caged-(S)-AMPA is a caged neurotransmitter analogue that uses NPEC photoprotective groups to cage (S)-AMPA so that the caged ligand can react with glutamate. |
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V70394 | NS-102 | 136623-01-3 | NS-102 is a selective kainate (GluK2) receptor blocker (antagonist). |
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V70473 | NS1219 ((R)-SPD502) | 233603-81-1 | NS1219 ((R)-SPD502) is an isomer of NS 1209. |
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V70407 | NYX-2925 | 2012536-16-0 | NYX-2925 is an orally bioavailable NMDAR modulator. |
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V70466 | Oleoyl-D-lysine | 2240164-55-8 | Oleoyl-D-lysine is a lipid-based, selective inhibitor of glycine transporter-2 (GlyT2). |
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V70429 | Onfasprodil | 1892581-29-1 | Onfasprodil is a NAM (negative allosteric modulator) of NR2B. |
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V70424 | Org-26576 | 100044-96-0 | Org-26576 is a positive allosteric modulator (PAM) of AMPA receptors. |
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V79048 | Orphenadrine-d3 citrate (orphenadrine d3 (citrate)) | Orphenadrine-d3 (citrate) is the deuterated form of Orphenadrine citrate. | |
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V70470 | Orphenadrine-d3 hydrochloride | 1309283-23-5 | Orphenadrine-d3 ( HCl) is the deuterated form of Orphenadrine HCl. |
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