Size | Price | Stock | Qty |
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1mg |
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5mg |
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10mg |
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50mg |
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Other Sizes |
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Targets |
NMDA Receptor
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ln Vitro |
Similar caspase-3 activation is produced by PEAQX (3 μM), although NVP-AAM007 is almost three times more powerful [2].
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ln Vivo |
PEAQX (10–40 mg/kg) enhances cortical caspase-3 activity after subchronic treatment in a dose-dependent manner [2]. In contrast to saline pretreatment, PEAQX (10 and 20 mg/kg) increased locomotor activity in response to PCP challenge (4 mg/kg on PN28–35) [2]. Even with learning and memory impairment, PEAQX (10 mg/kg, i.p.) counteracts the effects of PRE084 on CaMKIV-TORC1-CREB and BDNF [3].
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Animal Protocol |
Animal/Disease Models: Timed, day 14 pregnant female SD (Sprague-Dawley) rats[2].
Doses: 10, 20 or 40 mg/kg. Route of Administration: SC Experimental Results: demonstrated a sensitized locomotor response to PCP challenge on PN28-35. Animal/Disease Models: Timed , day 14 pregnant female SD (Sprague-Dawley) rats[2]. Doses: 4 mg/kg. Route of Administration: IP Experimental Results: Did not Dramatically increase locomotor activity in rats treated sub-chronically with PEAQX on PN7, 9 and 11. Animal/Disease Models: 11 -week old C57BL/6 mice[3]. Doses: 10 mg/kg. Route of Administration: IP. Experimental Results: Reversed the effect of PRE084 (F3,78 = 10.446, p<0.01). |
References |
[1]. Auberson YP, et al. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102.
[2]. Anastasio NC, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163(4):1181-91. [3]. Qian Xu, et al. Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. J Neurol Sci. 2017 May 15;376:166-175. |
Molecular Formula |
C17H15BRN3NA4O6P
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Molecular Weight |
560.15
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Related CAS # |
PEAQX;459836-30-7
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O :~25.5 mg/mL (~45.52 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (178.52 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.7852 mL | 8.9262 mL | 17.8524 mL | |
5 mM | 0.3570 mL | 1.7852 mL | 3.5705 mL | |
10 mM | 0.1785 mL | 0.8926 mL | 1.7852 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.