A family of enzymes known as monoamine oxidases (MAO) catalyzes the oxidation of monoamines. In the majority of the body's cell types, they are discovered bound to the mitochondria's outer membrane. They are a member of the flavin-containing amine oxidoreductase protein family. The oxidative deamination of monoamines is catalyzed by monoamine oxidases. By using oxygen to remove an amine group from a molecule, the resulting aldehyde and ammonia are produced.Flavoproteins are monoamine oxidases because they have the cofactor FAD covalently bound to them. MAO dysfunction is thought to be the cause of a number of psychiatric and neurological disorders due to the critical part MAOs play in the inactivation of neurotransmitters. While MAO-B inhibitors are used alone or in combination to treat Alzheimer's and Parkinson's diseases, MAO-A inhibitors have antidepressant and antianxiety properties.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V70679 | Homopterocarpin ((-)-Homopterocarpin; 3,9-Dimethoxypterocarpan) | 606-91-7 | Homopterocarpin is an isoflavone that can be extracted from Pterocarpus erinaceus. |
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V70658 | Hydroxylamine-d3 hydrochloride (hydroxylamine hydrochloride-d3; hydroxylamine hydrochloride-d3) | 15588-23-5 | Hydroxylamine-d3 ( HCl) is the deuterated form of Hydroxyamine HCl. |
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V20851 | Hypericin (SGX301) | 548-04-9 | Hypericin(also known as SGX301), is a novel, first-in-class photodynamic therapy using a potent photosensitizer, synthetic hypericin, that is topically applied and activated by safe visible fluorescent light. |
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V80226 | IHC3 | IHC3 is a competitive and reversible inhibitor of MAO-B (IC50= 1.672 μM). | |
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V3149 | Iproniazid | 54-92-2 | Iproniazid (brand/other names of Marsilid, Rivivol, Euphozid, Iprazid, Ipronid, Ipronin) is a non-selective, and irreversiblemonoamine oxidase inhibitor (MAOI). |
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V22802 | J147 | 1146963-51-0 | J147 is a potent neuroprotective and neurotrophic compound. |
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V70650 | Kynuramine dihydrobromide | 304-47-2 | Kynuramine diHBr is an endogenous amine and a fluorescent substrate for plasma amine oxidase. |
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V70642 | Kynuramine dihydrochloride | 36681-58-0 | Kynuramine is an endogenous amine and a fluorescent substrate and probe for plasma amine oxidase. |
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V70692 | Ladostigil (TV-3326) | 209394-27-4 | Ladostigil (TV-3326) is an orally bioavailable dual (bifunctional) inhibitor of cholinesterase (cholinesterase) and brain-selective monoamine oxidase (MAO). |
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V70691 | Ladostigil hemitartrate (TV-3326 hemitartrate) | 209394-46-7 | Ladostigil (TV-3326) hemitartrate is an orally bioavailable dual (bifunctional) inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO). |
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V70694 | Ladostigil hydrochloride (TV-3326 hydrochloride) | 209394-18-3 | Ladostigil (TV-3326) HCl is an orally bioavailable dual (bifunctional) inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO). |
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V4155 | Lazabemide | 103878-84-8 | Lazabemide (also known as Ro 19-6327; proposed trade namesPakio,Tempium) is novel, potent, selective, reversible monoamine oxidase B (MAO-B) inhibitor with IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively. |
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V70695 | Lazabemide hydrochloride (Ro 19-6327 hydrochloride) | 103878-83-7 | Lazabemide HCl (Ro 19-6327 HCl) is a selective and reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM), but has low activity against MAO-A (IC50>100 μM). |
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V41859 | LOX-IN-3 dihydrochloride | 2409964-23-2 | LOX-IN-3 (PXS5505; PXS-5505) dihydrochloride is a novel and oral inhibitor of lysyl oxidase (LOX)with potential usefulness for treatment of a variety of disorders, e. |
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V70649 | LOX-IN-3 dihydrochloride monohydrate | 2414974-55-1 | LOX-IN-3 diHCl monohydrate (Compound 33) is an orally bioactive lysyl oxidase (LOX) inhibitor for fibrosis, cancer and angiogenesis research. |
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V80144 | Lysyl hydroxylase 2-IN-1 | Lysyl hydroxylase 2-IN-1 (compound 12) is a selective lysyl hydroxylase 2 (LH2) inhibitor (antagonist) with IC50 of approximately 300 nM. | |
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V80029 | Lysyl hydroxylase 2-IN-2 | Lysyl hydroxylase 2-IN-2 (compound 13) is a potent inhibitor of Lysyl hydroxylase 2 (LH2) with IC50 of approximately 500 nM. | |
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V2308 | Lysyl oxidase inhbitor 1 | 2409963-83-1 | Lysyl oxidase inhbitor 1 is a novel and potent inhibitor of lysyl oxidase, whose upregulation by tumor cells may promote metastasis of the existing tumor, causing it to become malignant and cancerous. |
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V70688 | MAO-A/5-HT2AR-IN-1 | 2769156-00-3 | MAO-A/5-HT2AR-IN-1 (compound I14) is a potent dual (bifunctional) inhibitor of MAO-A and 5-HT2AR with IC 50 of 0.004 and 0.014 μM, respectively. |
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V80133 | MAO-A/B-IN-2 | MAO-A/B-IN-2 (Compound 30) is an MAO-A/B inhibitor (antagonist) with IC50s of 17.8 and 15.8 μM for MAO-A and MAO-B, respectively. |
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