| Size | Price | Stock | Qty |
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| 10mg |
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| ln Vitro |
In vitro, kappamine inhibits alpha-adrenergic receptors on the postsynaptic and presynaptic levels [2]. It has been demonstrated that kynuramine partially agonistically interacts with serotonin receptors in canine cerebral arteries [2]. The ileum frequently contracts slightly when exposed to 20 μg/mL of kynuramine, but this does not change the twitching response to cholinergic stimulation [2].
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| ln Vivo |
It is possible that kynuramine (0.064, 0.32, 1.6, or 8 μg; intracerebroventricular; single dose) regulates female sexual behavior physiologically[3]. Kynuramine (1.25, 2.5, and 5.0 mg/kg; intravenously; single dose) raises heart rate and blood pressure in intramedullary rats[4].
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| Animal Protocol |
Animal/Disease Models: Female rats[3].
Doses: 0.064-8 μg. Route of Administration: Intraventricular administration; single does. Experimental Results: Produced facilitation of lordosis behavior. Animal/Disease Models: Male rats (about 200g)[4]. Doses: 1.25-5.0 mg/kg. Route of Administration: iv; single does. Experimental Results: Promoted heart rate and blood pressure. |
| References |
[1]. J B Massey, et al. Kynuramine, a fluorescent substrate and probe of plasma amine oxidase. J Biol Chem. 1977 Nov 25;252(22):8081-4.
[2]. T D Johnson, An alpha-adrenoceptor inhibitory action of kynuramine. Eur J Pharmacol. 1981 Jul 10;72(4):351-6. [3]. S D Mendelson, et al. Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat. Eur J Pharmacol. 1987 Oct 27;142(3):447-51. [4]. T D Johnson, et al. Blood pressure and heart rate effects of kynuramine in pithed rats. Eur J Pharmacol. 1983 Feb 18;87(2-3):323-6. |
| Molecular Formula |
C9H14CL2N2O
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|---|---|
| Molecular Weight |
237.13
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| CAS # |
36681-58-0
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| Related CAS # |
Kynuramine dihydrobromide;304-47-2
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| SMILES |
Cl.Cl.NCCC(C1C=CC=CC=1N)=O
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 125 mg/mL (527.14 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (8.77 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (8.77 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.2171 mL | 21.0855 mL | 42.1710 mL | |
| 5 mM | 0.8434 mL | 4.2171 mL | 8.4342 mL | |
| 10 mM | 0.4217 mL | 2.1085 mL | 4.2171 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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