A family of enzymes known as monoamine oxidases (MAO) catalyzes the oxidation of monoamines. In the majority of the body's cell types, they are discovered bound to the mitochondria's outer membrane. They are a member of the flavin-containing amine oxidoreductase protein family. The oxidative deamination of monoamines is catalyzed by monoamine oxidases. By using oxygen to remove an amine group from a molecule, the resulting aldehyde and ammonia are produced.Flavoproteins are monoamine oxidases because they have the cofactor FAD covalently bound to them. MAO dysfunction is thought to be the cause of a number of psychiatric and neurological disorders due to the critical part MAOs play in the inactivation of neurotransmitters. While MAO-B inhibitors are used alone or in combination to treat Alzheimer's and Parkinson's diseases, MAO-A inhibitors have antidepressant and antianxiety properties.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70682 | MAO-B-IN-10 | 2376710-36-8 | MAO-B-IN-10 (compound 4f) is a specific, BBB (blood-brain barrier) penetrating MAO-B (monoamine oxidase-B) inhibitor (antagonist) with IC50 of 5.3 μM. |
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V70689 | MAO-B-IN-17 | 2890188-81-3 | MAO-B-IN-17 is a selective monoamine oxidase B (MAO-B) inhibitor (antagonist) with IC50 of 5.08 μM and may be utilized in the study of PD/Parkinson's disease. |
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V79013 | MAO-B-IN-18 | MAO-B-IN-18 is a potent and specific MAO B inhibitor (antagonist) with IC50 of 52 nM and 14 μM for hMAO B and hMAO A respectively. | |
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V70646 | MAO-B-IN-2 | 1253978-24-3 | MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC50s of 0.51 and 7.00 μM, respectively. |
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V79879 | MAO-B-IN-20 | MAO-B-IN-20 (Compound C14) is a potent inhibitor of MAO-B with IC50 of 0.037 μM. | |
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V70699 | MAO-B-IN-21 | 2956426-18-7 | MAO-B-IN-21 is a potent MAO-B inhibitor (antagonist) with anti-oxidant effect and anti-Aβ aggregation activity. |
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V70663 | MAO-B-IN-23 | 2107978-22-1 | MAO-B-IN-23 (Compound 11f) is a reversible and competitive MAO-B inhibitor (IC50= 1.44 μM, Ki= 0.51 μM). |
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V80681 | MAO-B-IN-25 | MAO-B-IN-25 (compound 92) is a selective MAO-B inhibitor (antagonist) with IC50s of 0.5 nM and 240 nM for MAO-A and MAO-B, respectively. | |
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V70656 | MAO-B-IN-27 | 788824-83-9 | MAO-B-IN-27 (Compound 12c) is a monoamine oxidase B (MAO-B) inhibitor. |
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V79144 | MAO-B-IN-3 | MAO-B-IN-3 is a reversible and selective MAO-B inhibitor (IC50=96 nM). | |
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V80682 | MAO-B-IN-4 | MAO-B-IN-4 (Compound 26) is an orally bioactive, reversible inhibitor of MAO-B with IC50 of 9 nM. | |
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V70655 | MAO-IN-3 | 797805-26-6 | MAO-IN-3 (Compound 5) is a reversible and competitive inhibitor of MAO (Ki: 0.6 and 0.2 μM for MAO A and MAO B, respectively). |
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V70683 | MAO-IN-M30 dihydrochloride | 64821-19-8 | MAO-IN-M30 di-HCl is an orally bioactive, BBB (blood-brain barrier)-passing, brain-selective and irreversible inhibitor of MAO-A (IC50=37 nM) and MAO-B (IC50=57 nM). |
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V80680 | MAOA-IN-1 | MAOA-IN-1 (compound 15) is an orally bioavailable MAOA inhibitor (antagonist) with cytotoxic effect against prostate cancer cells. | |
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V70665 | Mebanazine | 65-64-5 | Mebanazine is a potent MAO (monoamine oxidase) inhibitor. |
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V70690 | Methyl citrate | 26163-61-1 | Methyl citrate is a monoamine oxidase B (MAO-B) inhibitor (IC50=0.23 mM). |
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V70697 | Methyl piperate | 6190-46-1 | Methylpiperate is a piperine alkaloid with significant MAO inhibitory activity (IC50 3.6 μM). |
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V25757 | Mofegiline HCl | 120635-25-8 | Mofegiline HCl(MDL-72,974; MDL72,974), the hydrochloride salt ofMofegiline, is a potent andirreversibleinhibitor of monoamine oxidase B (MAO-B) and semicarbazide-sensitive amine oxidase (SSAO)with the potential to be used for the treatment for various diseases. |
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V70675 | Monoamine oxidase | 9001-66-5 | Monoamine oxidase is an enzyme consisting of different polypeptides. |
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V70687 | Monoamine Oxidase B inhibitor 1 | 2807477-70-7 | Monoamine Oxidase B inhibitor 1 is a potent, reversible, orally bioactive and selective inhibitor of monoamine oxidase B (MAO-B) with IC50 of 0.02 nM. |
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