Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs.All members of the Ras protein family are involved in signal transmission within cells and are members of the small GTPase protein class. The archetypal member of the Ras superfamily of proteins, which controls a variety of cell behaviors and is connected in three dimensions, is called Ras. Incoming signals cause Ras to become "switched on," which in turn causes other proteins to become "switched on," which in turn activates genes related to cell division, growth, and survival. Ras proteins that are permanently activated can therefore be produced as a result of mutations in the ras gene.Even in the absence of incoming signals, this can result in unwanted and excessive signaling within the cell. Overactive Ras signaling can eventually result in cancer because these signals cause cell growth and division. The most prevalent oncogenes in human cancer are the three Ras genes (HRAS, KRAS, and NRAS); Ras inhibitors are being researched as a potential treatment for cancer and other disorders where Ras overexpression occurs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V74738 | pan-KRAS-IN-4 | 2885961-55-5 | pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor (antagonist) with IC50s of 0.37 nM (Kras G12C) and 0.19 nM (Kras G12V). |
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V74734 | PAT-IN-1 | 2066571-97-7 | PAT-IN-1 is a protein acyltransferase (PAT) inhibitor. |
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V74743 | PAT-IN-2 | 2066572-01-6 | PAT-IN-2 is a protein acyltransferase (PAT) inhibitor. |
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V74741 | PROTAC KRAS G12C degrader-3 | 2768099-51-8 | PROTAC KRAS G12C degrader-3 (Comp 283) is a potent KRAS G12C degrader that may be utilized in cancer-related research. |
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V74729 | Rac1 Inhibitor W56 | 1095179-01-3 | Rac1 Inhibitor W56 is residues 45-60 in Rac1. |
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V74731 | Rac1-IN-3 | 380470-06-4 | Rac1-IN-3 (Compound 2) is a Rac1 inhibitor (antagonist) with IC50 of 46.1 μM. |
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V74728 | Ras modulator-1 | 623935-08-0 | Ras modulator-1 is a Ras modulator. |
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V2502 | Rasarfin | 674359-73-0 | Rasarfin is a novel dual Ras and ARF6 inhibitor,which blocks agonist-mediated internalization of AT1R and other GPCRs. |
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V2949 | RBC8 | 361185-42-4 | RBC8 is a novel and potent inhibitor of Ral GTPase with IC50 of 3.5 μM in H2122 cells and 3.4 μM in H358 cells. |
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V74725 | RMC-4998 | 2642037-07-6 | RMC-4998 is a molecular glue compound with good anti-tumor activity. |
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V74722 | RMC-7977 | 2765082-12-8 | RMC-7977 is a reversible tricomplex RAS inhibitor (antagonist) with broad-spectrum activity against mutant and wild-type (WT) KRAS, NRAS and HRAS variants. |
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V74740 | RTIL 13 | 1009376-10-6 | RTIL 13 is a potent dynamin GTPase inhibitor (antagonist) with IC50 of 2.3 µM for dynamin I GTPase. |
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V74705 | SAH-SOS1A TFA | 2896737-31-6 | SAH-SOS1A TFA is a bioactive peptide-based inhibitor of the SOS1/KRAS protein interaction. |
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V74714 | SOS1-IN-10 | 2758690-15-0 | SOS1-IN-10 is a potent SOS1 inhibitor (antagonist) with IC50 of 13 nM against KRAS G12C-SOS1. |
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V74727 | SOS1-IN-3 | 2359689-76-0 | SOS1-IN-3 is a potent inhibitor of SOS1 with IC50 of 5 nM. |
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V74710 | SOS1-IN-9 | 2758900-76-2 | SOS1-IN-9 is a potent SOS1 inhibitor (antagonist) with IC50 of 116.5 nM against KRAS G12C-SOS1. |
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V3449 | Sotorasib (AMG-510) | 2296729-00-3 | Sotorasib (AMG-510; AMG510; Lumakras; Lumykras) is a novel, first-in-class and covalent/irreversible inhibitor of KRAS G12C that has been approved by FDA on 5/28/2021 to treat non-small-cell lung cancer (NSCLC). |
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V74737 | StRIP16 | 2761279-63-2 | StRIP16, a bioavailable StRIP3 analog, is a double-stapled peptide that binds to Rab8a GTPase with a Kd of 12.7 μM. |
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V74703 | TH-Z827 | 2847881-81-4 | TH-Z827 is a mutant-selective KRAS(G12D) inhibitor (antagonist) with IC50 of 2.4 μM. |
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V28342 | Y16 | 429653-73-6 | Y16, formerly known as RhoA-IN-Y16, is a RhoA inhibitor, Y16 blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor, with Rho (Kd = 80 nM). |
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