Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs.All members of the Ras protein family are involved in signal transmission within cells and are members of the small GTPase protein class. The archetypal member of the Ras superfamily of proteins, which controls a variety of cell behaviors and is connected in three dimensions, is called Ras. Incoming signals cause Ras to become "switched on," which in turn causes other proteins to become "switched on," which in turn activates genes related to cell division, growth, and survival. Ras proteins that are permanently activated can therefore be produced as a result of mutations in the ras gene.Even in the absence of incoming signals, this can result in unwanted and excessive signaling within the cell. Overactive Ras signaling can eventually result in cancer because these signals cause cell growth and division. The most prevalent oncogenes in human cancer are the three Ras genes (HRAS, KRAS, and NRAS); Ras inhibitors are being researched as a potential treatment for cancer and other disorders where Ras overexpression occurs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V74719 | Z62954982 (ZINC08010136) | 1090893-12-1 | Z62954982 (ZINC08010136) is a specific, cell-permeable (penetrable) Rac1 (IC50=12 μM) inhibitor that is 4 times more effective than NSC23766 (IC50=50 μM). |
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V5241 | ZT-12-037-01 | 2328073-61-4 | ZT-12-037-01 is a novel, potent, ATP-competitive and specific STK19-targeted inhibitor with IC50s of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. |
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