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Ras

Ras

Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs.All members of the Ras protein family are involved in signal transmission within cells and are members of the small GTPase protein class. The archetypal member of the Ras superfamily of proteins, which controls a variety of cell behaviors and is connected in three dimensions, is called Ras. Incoming signals cause Ras to become "switched on," which in turn causes other proteins to become "switched on," which in turn activates genes related to cell division, growth, and survival. Ras proteins that are permanently activated can therefore be produced as a result of mutations in the ras gene.Even in the absence of incoming signals, this can result in unwanted and excessive signaling within the cell. Overactive Ras signaling can eventually result in cancer because these signals cause cell growth and division. The most prevalent oncogenes in human cancer are the three Ras genes (HRAS, KRAS, and NRAS); Ras inhibitors are being researched as a potential treatment for cancer and other disorders where Ras overexpression occurs.

Ras related products

Structure Cat No. Product Name CAS No. Product Description
V2944 K-Ras-IN-1 84783-01-7 K-Ras-IN-1 (formerly known as K-Ras-Inhibitor-1) is a novel small molecule K-Ras inhibitor that binds to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure, in other words, K-Ras-IN-1 binds directly to K-Ras between switch I and switch II and inhibit Sos-catalyzed K-Ras activation.
V74735 K-Ras-IN-2 905794-70-9 K-Ras-IN-2 (Compound CHI-000-667) is a K-Ras antagonist that may be utilized in tumor-related research.
V5211 Kobe-2602 454453-49-7 kobe2602 is a novel, potent and selective small-molecule inhibitor of Ras–Raf interaction identified by SBDD (structure based drug design); it exhibits competitively inhibits the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 149 ± 55 μM.
V74706 KRAS G12C inhibitor 32 2756739-00-9 KRAS G12C inhibitor 32 is an eight-membered N-containing heterocyclic compound and an effective KRAS G12C inhibitor.
V74739 KRAS G12C inhibitor 38 2660129-56-4 KRAS G12C inhibitor 38 is a potent KRAS G12C inhibitor.
V74709 KRAS G12C inhibitor 44 2927439-07-2 KRAS G12C inhibitor 44 (compound 54) is a potent and orally bioactive KRAS G12C inhibitor.
V74713 KRAS G12C inhibitor 59 2914919-88-1 KRAS G12C inhibitor 59 is an inhibitor (blocker/antagonist) of KRAS G12C with anti-cancer effects (WO2023036282A1, compound II).
V74742 KRAS G12D inhibitor 12 2648552-54-7 KRAS G12D inhibitor 12 is a potent KRAS G12D inhibitor.
V74712 KRAS inhibitor-11 2761218-40-8 KRAS inhibitor-11 (compound 12) is a KRAS inhibitor.
V74724 KRAS mutant protein inhibitor 1 2642630-16-6 KRAS mutant protein inhibitor 1 is a KRAS mutant protein inhibitor for potential cancer research.
V74711 Kras4B G12D-IN-1 2042365-85-3 Kras4B G12D-IN-1 is an inhibitor (blocker/antagonist) of Kras4B G12D with anti-cancer effects.
V74721 LUNA18 2676177-63-0 LUNA18 is an orally bioactive KRAS inhibitor (antagonist) with IC50 of <2 nM for KRASG12D-SOS.
V3973 MBQ-167 2097938-73-1 MBQ-167 (MBQ167) is a dualinhibitor of Rac/Cdc42 (Ras-related C3 botulinum toxin substrate and cell division control protein 42 homolog) with anticancer activity.
V29442 Methylophiopogonanone B 74805-91-7 Methylophiopogonanone B, a high isoflavone found in the roots of Ophiopogon japonicus, has high antioxidant capacity.
V4020 ML-098 878978-76-8 ML098 (also known as CID-7345532) is a potent activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM.
V74718 MLS000532223 16616-39-0 MLS000532223 is a selective, high-affinity inhibitor of Rho family GTPases (Rho family GTPases) with EC50 in the range of 16-120 μM.
V41722 MRTX0902 2654743-22-1 MRTX0902 (MRTX-0902) isa novel, potent, selective, brain-penetrant, and orally bioavailable SOS1 binder that disrupts the SOS1:KRASG12CPPI (protein-protein interaction) with a binding Ki of 1.9 nM and IC50 of 29 nM in MKN1 cells.
V74732 Neogrifolin 23665-96-5 Neogrifolin is an inhibitor (blocker/antagonist) of KRAS.
V74736 pan-KRAS-IN-2 2882825-14-9 pan-KRAS-IN-2 (compound 6) is a pan-inhibitor (antagonist) with IC50≤10 nM for KRAS WT and mutants (G12D, G12C, G12V, G12S, G12A, Q61H); IC50 for KRAS G13D is greater than 10 μM.
V74716 pan-KRAS-IN-3 2875116-29-1 pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor.
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