Opioid ligands are a class of G protein-coupled receptors known as opioid receptors. Dynorphins, enkephalins, endorphins, endomorphins, and nociceptin are examples of endogenous opioids. There are many opioid receptors in the brain, as well as in the spinal cord and digestive system. The body has molecules or sites called opioid receptors that are triggered by opioid substances. Opioid receptors prevent impulses from traveling along excitatory pathways in the human body.The serotonin, catecholamine, and substance P pathways are some of these pathways, and they are all thought to play a role in pain perception and feelings of wellbeing. Mu, delta, and kappa receptors are additional subclassifications of opioid receptors. While each class has its own unique way of acting, they all have some fundamental things in common. The potassium pump mechanism, which is present on the plasma membrane of most cells, powers them all.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V69959 | Orphanin FQ(1-11) | 178249-41-7 | Orphanin FQ(1-11), an orphan protein FQ or nociceptin (OFQ/N) fragment, is a potent NOP (ORL-1; OP4) receptor agonist/activator with a Ki of 55 nM. |
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V81014 | Orphanin FQ(1-11) TFA | Orphanin FQ(1-11) TFA, an orphan protein FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist/activator with a Ki of 55 nM. | |
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V69974 | Picraline | 2671-32-1 | Picraline is a naturally occurring alkaloid that targets opioid receptors. |
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V81164 | PL-017 TFA | PL-017 TFA is a specific μ opioid receptor agonist/activator with IC50 of 5.5 nM for 125I-FK 33,824 binding to the μ site. | |
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V29494 | Porcine dynorphin A(1-13) | 72957-38-1 | Porcine dynorphin A (1-13) is a potent endogenous κ opioid receptor agonist (activator) that relieves pain at physiological concentrations. |
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V8817 | PZM21 | 1997387-43-5 | PZM21 is a novel, potent and selective Gi activator with exceptional selectivity for μ opioid receptor (μOR) and minimal β-arrestin-2 recruitment with an EC50 of 1.8 nM. |
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V1278 | Racecadotril (acetorphan) | 81110-73-8 | Racecadotril (also called acetorphan) is a potent and peripherally acting enkephalinase inhibitor used as an antidiarrheal medication. |
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V69920 | Riminkefon | 2168572-99-2 | Riminkefon is a kappa opioid receptor agonist (activator). |
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V76529 | SB-612111 hydrochloride | SB-612111 HCl is a new and highly effective opioid receptor orphan receptor (ORL-1) antagonist (inhibitor) with high affinity for hORL-1 (Ki=0.33 nM). | |
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V69898 | SC13 | 2839142-69-5 | SC13 is a new mitragynine analog with low potency Mu opioid receptor agonism, anesthetic effects and mild adverse reactions. |
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V14985 | SNC80 | 156727-74-1 | SNC80 (SNC-80; SNC 80) is a novel, potent, selective, systemically active non-peptide δ(delta)-opioid agonist with potential antinociceptiveand pro-convulsant activities in vivo. |
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V69903 | Spiradoline (U-62066) | 87151-85-7 | Spiradoline (U-62066), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist/activator with a Ki of 8.6 nM in guinea pigs. |
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V69889 | Spiradoline mesylate (U-62066 mesylate) | 87173-97-5 | Spiradoline mesylate (U-62066 mesylate) is an arylacetamide and a selective kappa opioid receptor (κ-opioid receptor (KOR)) agonist/activator with a Ki of 8.6 nM in guinea pigs. |
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V69966 | SR-16435 | 857262-16-9 | SR-16435 is a partial agonist of NOP/μ-opioid receptor with high binding affinity (NOP receptor Ki=7.49; μ-opioid receptor Ki=2.70). |
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V3190 | SR17018 | 2134602-45-0 | SR17018 is an agonist of the μ-opioid-receptor (MOR) which binds to GTPγS with EC50 value of 97 nM. |
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V69897 | Sunobinop (S 117957; IMB 115) | 1126793-40-5 | Sunobinop (S 117957) is a modulator of the opioid receptor-like orphan receptor (ORL1). |
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V69914 | TAN-452 | 892039-23-5 | TAN-452 is an orally bioactive, selective, peripherally acting delta opioid receptor (DOR) antagonist (inhibitor) with a Ki of 0.47 nM and a Kb of 0.21 nM. |
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V69916 | Tegileridine | 2095345-66-5 | Tegileridine is a potent agonist of the opioid receptor (MOR). |
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V69900 | Trap-101 hydrochloride | 1216621-00-9 | Trap-101 HCl is a specific and competitive antagonist of NOP receptors, with selectivity for NOP receptors over other opioid receptors. |
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V1281 | Trimebutine | 39133-31-8 | Trimebutine (Mebutin; Debridat; Polibutin; Modulon; Dromostat; Ibutin; Polibutin; TM 906; Trimedat)is a potent agonist of peripheral mu, kappa and delta(μ,κ, andδ)opioid receptors. |
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