Opioid ligands are a class of G protein-coupled receptors known as opioid receptors. Dynorphins, enkephalins, endorphins, endomorphins, and nociceptin are examples of endogenous opioids. There are many opioid receptors in the brain, as well as in the spinal cord and digestive system. The body has molecules or sites called opioid receptors that are triggered by opioid substances. Opioid receptors prevent impulses from traveling along excitatory pathways in the human body.The serotonin, catecholamine, and substance P pathways are some of these pathways, and they are all thought to play a role in pain perception and feelings of wellbeing. Mu, delta, and kappa receptors are additional subclassifications of opioid receptors. While each class has its own unique way of acting, they all have some fundamental things in common. The potassium pump mechanism, which is present on the plasma membrane of most cells, powers them all.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V69915 | GR 89696 free base | 126766-31-2 | GR 89696 free base is a selective κ2 opioid receptor agonist (activator) with the potential to prevent pruritus. |
|
V69934 | H-Ser-Tyr-OH | 21435-27-8 | H-Ser-Tyr-OH is a dipeptide consisting of glutamic acid, glycine and histidine. |
|
V69955 | Helianorphin-19 | 2883653-86-7 | Helianorphin-19 is a potent and specific κ-opioid receptor (KOR) activator with a Ki of 21 nM and EC50 of 45 nM. |
|
V69904 | Calcaprant | 2227384-17-8 | Icalcaprant is a kappa opioid receptor blocker (antagonist). |
|
V69950 | ICI 174864 | 89352-67-0 | ICI 174864 is a selective delta-receptor antagonist. |
|
V69946 | ICI-204448 | 121264-04-8 | ICI-204448 is a kappa-opioid agonist/activator with limited CNS entry. |
|
V1275 | JTC-801 HCl | 244218-51-7 | JTC-801 HCl (JTC 801; JTC801), the hydrochloride salt of JTC801, is a potent, orally bioactive and selective opioid receptor-like1 (ORL1) receptor antagonist with potential analgesic activity. |
|
V69975 | Leumorphin, human | 88846-98-4 | Leumorphin, human is a potent kappa opioid receptor agonist. |
|
V1277 | Lomerizine HCl (KB-2796) | 101477-54-7 | Lomerizine HCl (KB-2796; Migsis; KB2796; KB 2796), the dihydrochloride salt of Lomerizine, is a diphenylpiperazine-based, relatively new and potent L- and T-type CCB/calcium channel blocker used for the treatment of migraine. |
|
V1273 | Loperamide HCl (R-18553) | 34552-83-5 | Loperamide HCl (R18553; ADL-2-1294; R-18553; ADL 2-1294; Imodium; Dissenten; Fortasec), the hydrochloride salt of loperamide, is a potent and selective μ-opioid receptor agonist used to reduce the frequency of diarrhea, also for IBD-inflammatory bowel disease and short bowel syndrome. |
|
V69939 | Loperamide phenyl (Loperamide EP Impurity A) | 1391052-94-0 | Loperamide phenyl is an impurity in loperamide. |
|
V24690 | LY-2940094 tartrate | 1307245-87-9 | LY2940094 (BTRX-246040) tartrate is a potent, brain-permeable/penetrable, selective, orally administered NOP receptor blocker (antagonist) with high affinity (Ki=0.105 nM) and antagonism (Kb=0.166 nM). |
|
V69953 | LY255582 | 119193-09-8 | LY255582 is a pan-opioid antagonist (inhibitor) with high affinity for mu, delta and kappa receptors (Ki 0.4 nM, 5.2, 2.0 nM, respectively). |
|
V4848 | LY2795050 | 1346133-08-1 | LY2795050 is a novel, potent and selective κ-opioid Receptor (KOR) antagonist with an IC50 of 0.72 nM. |
|
V4864 | LY2940094 | 1307245-86-8 | LY-2940094 is a novel, potent, selective and orally bioavailable nociceptin receptor (NOP receptor) antagonist that can be potentially used for the treatment of major depressive disorder and alcoholism. |
|
V1280 | Meptazinol HCl | 59263-76-2 | Meptazinol (IL-22811; WY-22811; IL22811; WY22811; trade name Meptid), the hydrochloride salt of meptazinol, is a centrally actiing opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM. |
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V69896 | Methyl-6-alpha-Naltrexol | 116388-85-3 | Methyl-6-alpha-Naltrexol is the metabolite of methylnaltrexone (MNTX). |
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V69958 | Mitragynine pseudoindoxyl | 2035457-43-1 | Mitragynine pseudoindoxyl is a potent MOR agonist. |
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V69973 | MOR agonist-1 | 2305781-14-8 | MOR agonist-1 is a MOR (μ-opioid receptor) agonist. |
|
V80811 | MOR agonist-2 | MOR agonist-2 (Compound 46) is an antagonist of D3R and an agonist of MOR (Ki 7.26 nM and 564 nM respectively). |
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