Opioid ligands are a class of G protein-coupled receptors known as opioid receptors. Dynorphins, enkephalins, endorphins, endomorphins, and nociceptin are examples of endogenous opioids. There are many opioid receptors in the brain, as well as in the spinal cord and digestive system. The body has molecules or sites called opioid receptors that are triggered by opioid substances. Opioid receptors prevent impulses from traveling along excitatory pathways in the human body.The serotonin, catecholamine, and substance P pathways are some of these pathways, and they are all thought to play a role in pain perception and feelings of wellbeing. Mu, delta, and kappa receptors are additional subclassifications of opioid receptors. While each class has its own unique way of acting, they all have some fundamental things in common. The potassium pump mechanism, which is present on the plasma membrane of most cells, powers them all.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V4911 | Aticaprant (CERC-501) | 1174130-61-0 | Aticaprant (formerly also known as JNJ-67953964; LY-2456302; CERC501) is a novel, potent, oral, selective, CNS-penetrant and short-acting antagonist of the kappa/κ-opioid receptor (KOR) with aKiof 0.807 nM (versus 24.0 nM and 155 nM for the μ-opioid receptor (MOR) and δ-opioid receptor (DOR). |
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V69924 | BAN ORL 24 free base | 475150-69-7 | BAN ORL 24 free base is a NOP receptor antagonist. |
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V4694 | BAN-ORL-24 HCl | 1401463-54-4 | BAN ORL 24 is a novel, potent and selective NOP (nociceptin/orphanin FQ (N/OFQ) peptide receptor) receptor antagonist with IC50 values of 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively. |
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V69961 | Bilaid C | 2393866-13-0 | Bilaid C is a tetrapeptide extracted from the Australian estuarine Penicillium strain MST-MF667. |
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V69960 | Biphalin TFA | 126872-95-5 | Biphalin TFA is a brain barrier-penetrating opioid peptide analog containing two active enkephalin pharmacophores. |
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V69894 | BMS-986121 | 313671-26-0 | BMS-986121 is a PAM (positive allosteric modulator) of μ opioid receptor found in patent WO2014107344. |
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V69887 | BPR1M97 | 2059904-66-2 | BPR1M97 is a dual-acting (bifunctional) agonist at mu opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptors with Ki of 1.8 and 4.2 nM, respectively. |
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V50977 | BRL-52537 HCl | 112282-24-3 | BRL 52537 HCl is a selective kappa-opioid receptor (KOR) agonist/activator with Ki of 0.24 nM and 1560 nM for the kappa and mu subtypes, respectively. |
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V69883 | BW-180C ([D-Ala2, D-Leu5]-Enkephalin; DADLE) | 63631-40-3 | BW-180C ([D-Ala2, D-Leu5]-Enkephalin) is a water-soluble (H2O-soluble) peptide opioid receptor (Opioid Receptor) agonist. |
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V69888 | CCG258747 | 2615910-00-2 | CCG258747 is a selective GRK2 inhibitor (IC50=18 nM) with high selectivity for GRK1, GRK5, PKA and ROCK1 (518, 83, >5500 and >550-fold, respectively). |
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V3266 | Cebranopadol ((1α,4α)stereoisomer) | 863513-93-3 | Cebranopadol 1α,4α-stereoisomer is a stereoisomer of cebranopadol. |
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V69963 | Clocinnamox mesylate | 117332-69-1 | Clocinnamox (methanesulfonate) is a potent opioid antagonist that acts at mu, kappa and delta receptors. |
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V69945 | CR 665 (JNJ 38488502; FE 200665) | 228546-92-7 | CR 665 (JNJ 38488502) is a peripherally selective kappa-opioid agonist. |
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V78892 | CSD-CH2(1,8)-NH2 | CSD-CH2(1,8)-NH2 is a selective and competitive KOR antagonist (Ki: 6.8 nM). | |
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V69972 | CTAP | 103429-32-9 | CTAP is a specific, BBB (blood-brain barrier) permeable (penetrable) μ opioid receptor antagonist (inhibitor) with IC50 of 3.5 nM. |
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V77133 | CTAP TFA | CTAP TFA is a specific, BBB (blood-brain barrier) permeable (penetrable) μ opioid receptor antagonist (inhibitor) with IC50 of 3.5 nM. | |
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V77132 | CTOP TFA | CTOP TFA is a specific μ-opioid receptor antagonist. | |
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V2282 | CYM51010 | 1069498-96-9 | CYM51010 (also known as ML335; CYM-51010; CID23723457), is a biased ligand of μ-opioid receptor – δ-opioid receptor heterodimers (EC50=403 nM), exhibiting anti-nociceptive activity similar to morphine but with a decreased levels of tolerance development and withdrawal symptoms. |
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V69895 | Cyprodime | 118111-54-9 | Cyprodime is a selective μ opioid receptor (MOR) antagonist (inhibitor) with Ki of 5.4, 244.6, and 2187 nM for μ, δ, and κ, respectively. |
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V69901 | Cyprodime hydrochloride | 2387505-50-0 | Cyprodime HCl is a selective μ-opioid receptor antagonist (inhibitor) with Kis of 5.4 nM, 244.6 nM and 2187 nM for μ, δ and κ opioid receptors respectively. |
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