Size | Price | Stock | Qty |
---|---|---|---|
10mg |
|
||
25mg |
|
||
50mg |
|
||
100mg |
|
||
250mg |
|
||
500mg |
|
||
Other Sizes |
|
Purity: ≥98%
JTC-801 HCl (JTC 801; JTC801), the hydrochloride salt of JTC801, is a potent, orally bioactive and selective opioid receptor-like1 (ORL1) receptor antagonist with potential analgesic activity. It blocks opioid receptor-like1 (ORL1) with an IC50 of 94 nM.
Targets |
NOP Receptor/ORL1
|
|
---|---|---|
ln Vitro |
|
|
ln Vivo |
|
|
Enzyme Assay |
Membranes from human μ-opioid receptor-expressing CHO-K1 cells suspended in 50 mM Tris-HCl buffer (pH 7.4) with 10% sucrose, 5 mM MgCl2, and 0.33 nM 2H-labeled diprenorphine are incubated for 2.5 hours at room temperature with different concentrations of JTC-801. Whatman 934-AH is used to filter the membranes, and a TopCount A9912V scintillation counter is used to count radioactivity. 10 μM naloxone is used to measure nonspecific binding (6.4%). By deducting nonspecific binding from total binding, specific binding is computed. The mean±SE (n=3) is the data.
|
|
Animal Protocol |
|
|
References |
Molecular Formula |
C26H26CLN3O2
|
|
---|---|---|
Molecular Weight |
447.96
|
|
Exact Mass |
447.17
|
|
Elemental Analysis |
C, 69.71; H, 5.85; Cl, 7.91; N, 9.38; O, 7.14
|
|
CAS # |
244218-51-7
|
|
Appearance |
Solid powder
|
|
SMILES |
CCC1=CC=C(C=C1)OCC2=CC=CC=C2C(=O)NC3=CC4=C(C=C(N=C4C=C3)C)N.Cl
|
|
InChi Key |
NQLIYKXNAXKMBL-UHFFFAOYSA-N
|
|
InChi Code |
InChI=1S/C26H25N3O2.ClH/c1-3-18-8-11-21(12-9-18)31-16-19-6-4-5-7-22(19)26(30)29-20-10-13-25-23(15-20)24(27)14-17(2)28-25;/h4-15H,3,16H2,1-2H3,(H2,27,28)(H,29,30);1H
|
|
Chemical Name |
N-(4-amino-2-methylquinolin-6-yl)-2-[(4-ethylphenoxy)methyl]benzamide;hydrochloride
|
|
Synonyms |
|
|
HS Tariff Code |
2934.99.9001
|
|
Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
|
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
Solubility (In Vitro) |
|
|||
---|---|---|---|---|
Solubility (In Vivo) |
|
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.2323 mL | 11.1617 mL | 22.3234 mL | |
5 mM | 0.4465 mL | 2.2323 mL | 4.4647 mL | |
10 mM | 0.2232 mL | 1.1162 mL | 2.2323 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.