Size | Price | Stock | Qty |
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2mg |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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Other Sizes |
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Purity: ≥98%
PD 128907 HCl (PD-128907) is a novel, potent and selective dopamine D3 receptor agonist with EC50 of 0.64 nM, it exhibits 53-fold selectivity over dopamine D2 receptor. PD-128907 is frequently used as a tool compound to study how these receptors function in the brain, particularly as inhibitory autoreceptors, which act to prevent further dopamine release. Using [3H]spiperone as the radioligand in CHOKl-cells, PD 128907 shows approximately a 10000-fold selectivity versus human D4 receptors (Ki, 7000 nM) and a l000-fold selectivity for human D3 receptors (Ki, 1 nM) versus human D2 receptors (Ki, 1183 nM).
Targets |
D3 receptor ( EC50 = 0.64 nM )
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ln Vitro |
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ln Vivo |
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Enzyme Assay |
(+)-PD 128907 hydrochloride is a selective agonist of the D2/D3 dopamine receptor. Its Kis values for human and rat D3 receptors are 1.7, 0.84 nM, and 179, 770 n M, respectively.
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Animal Protocol |
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References |
Molecular Formula |
C14H20CLNO3
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Molecular Weight |
285.77
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Exact Mass |
285.11
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CAS # |
112960-16-4
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SMILES |
CCCN1CCO[C@H]2[C@H]1COC3=C2C=C(C=C3)O.Cl
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InChi Key |
DCFXOTRONMKUJB-QMDUSEKHSA-N
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InChi Code |
InChI=1S/C14H19NO3.ClH/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15;/h3-4,8,12,14,16H,2,5-7,9H2,1H3;1H/t12-,14-;/m1./s1
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Chemical Name |
(4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol;hydrochloride
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.4993 mL | 17.4966 mL | 34.9932 mL | |
5 mM | 0.6999 mL | 3.4993 mL | 6.9986 mL | |
10 mM | 0.3499 mL | 1.7497 mL | 3.4993 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.