BP897

Alias: BP-897; BP897; BP 897
Cat No.:V3385 Purity: ≥98%
BP 897 is a first potent and selective agonist of dopamine D3 receptor, and a weak antagonist of dopamine D2 receptor with Kis of 0.92 nM and 61 nM for D3 and D2 receptors.
BP897 Chemical Structure CAS No.: 314776-92-6
Product category: Dopamine Receptor
This product is for research use only, not for human use. We do not sell to patients.
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Other Forms of BP897:

  • BP 897
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

BP 897 is a first potent and selective agonist of dopamine D3 receptor, and a weak antagonist of dopamine D2 receptor with Kis of 0.92 nM and 61 nM for D3 and D2 receptors. It exhibits low affinities, with Ki values of 3 and 0.3 µM at the D1 and D4 receptors, respectively. In vitro, BP 897 functions as a partial agonist and can take on an antagonistic role in vivo. Without any intrinsic, primary rewarding effects, BP 897 inhibits cocaine-seeking behavior that is dependent on the presentation of drug-associated cues. According to the data, substances such as BP 897 may be used to lessen drug cravings and relapse susceptibility that are brought on by environmental cues related to drug use.

Biological Activity I Assay Protocols (From Reference)
Targets
D2 Receptor; D3 Receptor
ln Vitro
BP 897 hydrochloride adsorbs D1 and D4 (Ki=3 μM and 0.3 μM), α1 and α2 addin energy adsorption (Ki=60 nM and 83 nM) and 5HT1A and 5HT7 adsorption (Ki=84 nM and 345 nM) ) has affinity; it has negligible affinity for muscarinic, histamine and opioid receptors (Ki>1 μM)[1]. BP 897 hydrochloride inhibits forskolin-induced cyclic AMP accumulation in NG 108-15 cells expressing human D3 receptor with EC50=1 nM. BP 897 hydrochloride activates mitogenesis, and this response is preferentially induced by the D3 monoclonal antibody Nafadotride (1 μM) monoclonal antibody. BP 897 hydrochloride is also partially resistant to quinpirole (10 nM)-induced responses [1].
ln Vivo
BP 897 hydrochloride binds to D2 capture in the mouse striatum with an ED50 of 15 mg/kg and a D3 capture occupancy of less than 0.5 mg/kg[1]. Animal model: Male Listar hooded rat [1] Dosage: 0.05, 0.5, 1 mg/kg Administration: intraperitoneal injection; 30 minutes before treatment Results: Dose-dependent reduction in cocaine-seeking behavior prior to first infusion of cocaine, Doses were similar to those at which BP 897 responded to rotation and c-fos expression.
Animal Protocol
Male Listar hooded rats
0.05, 0.5, 1 mg/kg
i.p.; 30 min before the session
References

[1]. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist [published correction appears in Nature 1999 Sep 23;401(6751):403]. Nature. 1999;400(6742):371-375.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C26H31N3O2
Molecular Weight
417.54324
Exact Mass
417.24
Elemental Analysis
C, 74.79; H, 7.48; N, 10.06; O, 7.66
CAS #
314776-92-6
Appearance
Solid powder
SMILES
O=C(NCCCCN1CCN(C2=CC=CC=C2OC)CC1)C3=CC=C4C=CC=CC4=C3
InChi Key
MNHDKMDLOJSCGN-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H31N3O2/c1-31-25-11-5-4-10-24(25)29-18-16-28(17-19-29)15-7-6-14-27-26(30)23-13-12-21-8-2-3-9-22(21)20-23/h2-5,8-13,20H,6-7,14-19H2,1H3,(H,27,30)
Chemical Name
N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-2-naphthamide
Synonyms
BP-897; BP897; BP 897
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO : ~125 mg/mL (~275.33 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.3950 mL 11.9749 mL 23.9498 mL
5 mM 0.4790 mL 2.3950 mL 4.7900 mL
10 mM 0.2395 mL 1.1975 mL 2.3950 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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