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      Chlorpromazine HCl
      Chlorpromazine HCl

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      This product is for research use only, not for human use. We do not sell to patients.
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      InvivoChem Cat #: V1249
      CAS #: 69-09-0Purity ≥98%

      Description: Chlorpromazine HCl (Promacid; Chloractil; Klorpromex; Fenactil; Largactil; Propaphenin; Sonazine; Thorazine), the Hydrochloride salt form of chlorpromazine, is a potent dopamine and potassium channel inhibitor used as an antipsychotic medication for the treatment of psychotic disorders such as schizophrenia. It inhibits dopamine and potassium channel with IC50s of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents. Chlorpromazine HCl is a phenothiazine and traditional antipsychotic agent with anti-emetic activity. It exerts antipsychotic effect by blocking postsynaptic dopamine receptors in cortical and limbic areas of the brain, thereby preventing the excess of dopamine in the brain. 

      References: J Neurosci. 1999 Apr 1;19(7):2474-88; J Immunol. 1995 Jan 15;154(2):861-70.

      Related CAS #: 69-09-0 (HCl)   50-53-3 (free)  

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      Molecular Weight (MW)355.33
      FormulaC17H19ClN2S.HCl 
      CAS No.69-09-0
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 71 mg/mL (199.8 mM)
      Water: N/A
      Ethanol: 71 mg/mL (199.8 mM)
      Other info

      Chemical Name: 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride

      InChi Key: FBSMERQALIEGJT-UHFFFAOYSA-N

      InChi Code: InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

      SMILES Code: CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl

      Synonyms

      Promacid; Chloractil; Klorpromex; Fenactil; Hydrochloride, Chlorpromazine; Largactil; Propaphenin;Chloropromazine Hydrochloride; Sonazine; Thorazine


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      In Vitro

      In vitro activity: Chlorpromazine affects miniature IPSCs (mIPSCs) by decreasing the binding (kon) and by increasing the unbinding (koff) rates of GABAARs. Chlorpromazine modulates activated TRPA1 currents in a voltage-dependent way, leading to a block at positive potentials and an increased open probability at negative potentials.

      In VivoChlorpromazine independently down-regulates the production of various T cell-derived lymphokines (IL-2, IFN-gamma, IL-4, TNF, and GM-CSF) and up-regulates the secretion of IL-10 in an in vivo model of acute superantigen-driven immune activation. Chlorpromazine -mediated amplification of the SEB-driven Chlorpromazine secretion is accompanied by an enhanced IL-10 mRNA accumulation. Chlorpromazine protects mice, normal or adrenalectomized, and guinea pigs against lethality of LPS, and inhibits TNF serum levels. Chlorpromazine protects against LPS lethality when administered 30 minutes (min) before, simultaneously, or up to 10 min after LPS and is ineffective when given 30 min after LPS, paralleling the inhibitory effect on TNF production. Chlorpromazine significantly inhibits LPS lethality and hepatotoxicity in mice sensitized to LPS toxicity by actinomycin D, whereas under these conditions DEX is inactive. Chlorpromazine protects brain tissue from hypoxia-induced irreversible loss of synaptic transmission in rats. Chlorpromazine also significantly delays the occurrence of the hypoxia-induced spreading depression (SD) in rats.
      Animal modelRats
      Formulation & Dosage
      References

      J Neurosci. 1999 Apr 1;19(7):2474-88; J Immunol. 1995 Jan 15;154(2):861-70.

      These protocols are for reference only. InvivoChem does not independently validate these methods.

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