Description: Chlorpromazine HCl, the Hydrochloride salt form of chlorpromazine, is a potent dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents. Chlorpromazine HCl is a phenothiazine and traditional antipsychotic agent with anti-emetic activity. Chlorpromazine hydrochloride exerts its antipsychotic effect by blocking postsynaptic dopamine receptors in cortical and limbic areas of the brain, thereby preventing the excess of dopamine in the brain.
References: J Neurosci. 1999 Apr 1;19(7):2474-88; J Immunol. 1995 Jan 15;154(2):861-70.
Related CAS #: 69-09-0 (HCl) 50-53-3 (free)
Chemical Name: 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride
InChi Key: FBSMERQALIEGJT-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
SMILES Code: CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl
Promacid; Chloractil; Klorpromex; Fenactil; Hydrochloride, Chlorpromazine; Largactil; Propaphenin;Chloropromazine Hydrochloride; Sonazine; Thorazine
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
In vitro activity: Chlorpromazine affects miniature IPSCs (mIPSCs) by decreasing the binding (kon) and by increasing the unbinding (koff) rates of GABAARs. Chlorpromazine modulates activated TRPA1 currents in a voltage-dependent way, leading to a block at positive potentials and an increased open probability at negative potentials.
J Neurosci. 1999 Apr 1;19(7):2474-88; J Immunol. 1995 Jan 15;154(2):861-70.
Purity ≥98%
COA
MSDS