Chlorpromazine HCl

Alias:
Cat No.:V1249 Purity: ≥98%
Chlorpromazine HCl (Promacid; Chloractil; Klorpromex; Fenactil; Largactil; Propaphenin; Sonazine; Thorazine), the Hydrochloride salt form of chlorpromazine, is a potent dopamine and potassium channel inhibitor used as an antipsychotic medication for the treatment of psychotic disorders such as schizophrenia.
Chlorpromazine HCl Chemical Structure CAS No.: 69-09-0
Product category: Dopamine Receptor
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
500mg
1g
5g
10g
25g
Other Sizes

Other Forms of Chlorpromazine HCl:

  • Chlorpromazine
  • Chlorpromazine D6 hydrochloride
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Chlorpromazine HCl (Promacid; Chloractil; Klorpromex; Fenactil; Largactil; Propaphenin; Sonazine; Thorazine), the Hydrochloride salt form of chlorpromazine, is a potent dopamine and potassium channel inhibitor used as an antipsychotic medication for the treatment of psychotic disorders such as schizophrenia. It blocks the dopamine and potassium channels, exhibiting IC50 values of 6.1 and 16 μM for time-independent outward currents and inward-rectifying K+ currents, respectively. A classic antipsychotic drug with phenothiazine properties and anti-emetic properties is chlorpromazine hydrochloride (HCl). It prevents the brain from having too much dopamine by blocking postsynaptic dopamine receptors in limbic and cortical regions. This has an antipsychotic effect.

Biological Activity I Assay Protocols (From Reference)
Targets
D2 dopamine receptors; 5-HT2A
ln Vitro

In vitro activity: Chlorpromazine decreases GABAAR binding (kon) and increases GABAAR unbinding (koff) rates, which has an impact on miniature IPSCs (mIPSCs).[1] Voltage-dependent modulation of activated TRPA1 currents by chlorpromazine results in an increased open probability at negative potentials and a block at positive potentials.[2]

ln Vivo
Chlorpromazine independently increases the secretion of IL-10 and down-regulates the production of several T cell-derived lymphokines (IL-2, IFN-gamma, IL-4, TNF, and GM-CSF) in an in vivo model of acute superantigen-driven immune activation. An increased IL-10 mRNA accumulation coincides with the chlorpromazine-mediated amplification of the SEB-driven chlorpromazine secretion. [3]
Cell Assay
Cell Line: U-87MG glioma cells
Concentration: 0, 10, 20, 40 μM
Incubation Time: 0, 24, 48 h
Result: Showed anti-proliferative activity in a dose- and time-dependent manner.
Animal Protocol
5- to 6-week-old athymic nude mice bearing intracranial U-87MG xenograft tumors[2]
20 mg/kg
Injected intraperitoneally; single daily for 7 days
References

[1]. J Neurosci . 1999 Apr 1;19(7):2474-88.

[2]. J Biol Chem . 2007 Mar 9;282(10):7145-53.

[3]. J Immunol . 1995 Jan 15;154(2):861-70.

[4]. J Exp Med . 1991 Jun 1;173(6):1305-10.

[5]. Brain Res . 1986 Oct 22;385(2):219-26.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C17H20CL2N2S
Molecular Weight
355.33
Exact Mass
354.07
Elemental Analysis
C, 57.46; H, 5.67; Cl, 19.96; N, 7.88; S, 9.02
CAS #
69-09-0
Appearance
White to off-white crystalline powder
SMILES
CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl
InChi Key
FBSMERQALIEGJT-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
Chemical Name
3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride
Synonyms

Promacid; Chloractil; Klorpromex; Fenactil; Hydrochloride; Chlorpromazine; Largactil; Propaphenin; Chloropromazine Hydrochloride; Sonazine; Thorazine

HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: ~71 mg/mL (~199.8 mM)
Water: N/A
Ethanol: ~71 mg/mL (~199.8 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.8143 mL 14.0714 mL 28.1429 mL
5 mM 0.5629 mL 2.8143 mL 5.6286 mL
10 mM 0.2814 mL 1.4071 mL 2.8143 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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g/mol

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In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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Clinical Trial Information
NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05190315 Active
Recruiting
Radiation: Radiation Therapy
Drug: Chlorpromazine
Drug: Temozolomide
Glioblastoma Multiforme Mohammed Milhem January 28, 2022 Phase 1
NCT03021486 Active
Recruiting
Drug: Chlorpromazine
Drug: Haloperidol
Delirium
Advanced Malignant Neoplasm
M.D. Anderson Cancer Center June 5, 2017 Phase 2
Phase 3
NCT01404364 Completed Drug: Triamcinolone
Drug: Chlorpromazine
Blind Painful Eye
Refractory Glaucoma
Hospital Governador Celso Ramos January 2010 Not Applicable
NCT00202293 Completed Drug: Olanzapine
Drug: Lithium
Drug: Chlorpromazine
Bipolar Disorder
Schizoaffective Disorder
Melbourne Health October 1, 2001 Phase 4
NCT03639558 Completed Drug: Haloperidol + Promethazine Aggression
Agitation
Joseph Dib August 28, 2018 Phase 4
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