Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. Four AR subtypes have so far been cloned and found in various tissues. When exposed to agonists, these receptors exhibit unique localization, signal transduction pathways, and modes of regulation. The capacity of some Adenosine receptors to act as sensors of cellular oxidative stress, which is transmitted by transcription factors like NF-B to control the expression of ARs, is one of their key characteristics. We'll look at the role of adenosine receptors in the control of healthy and unhealthy processes, including sleep, the growth of cancer, and the prevention of hearing loss.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V17958 | Namodenoson (2 Cl-IB-MECA; CF102) | 163042-96-4 | Namodenoson (2-Cl-IB-MECA; CF102; CF-102) is a novel, potent, orally bioavailable, and highly selective adenosine A3 receptor (A3AR) agonist with potential anticancer activity. |
|
V2200 | NBMPR | 38048-32-7 | NBMPR(NBTI) is a nucleoside analog that competitively inhibits the equilibrative nucleoside transporter 1 (Kd = 0.1-1.0 nM, IC50s = 4.6 and 3.6 nM in rat and human, respectively). |
|
V11965 | Nicergoline | 27848-84-6 | Nicergoline tartrate is a naturally occuring ergot derivative and a vasoactive drug with α-adrenergic blocking activity, producing vasodilatation. |
|
V13165 | Norepinephrine (Levarterenol; L-Noradrenaline) | 51-41-2 | Norepinephrine (Levarterenol; L-Noradrenaline) is a potent and β1-selective adrenergic receptor agonist with EC50 of 5.37 μM. |
|
V75273 | NPC 200 (1,3-Dipropyl-8-phenylxanthine) | 85872-53-3 | NPC 200 is a potent Adenosine A1 Receptor selective antagonist. |
|
V13861 | Olodaterol | 868049-49-4 | Olodaterol (formerly known as BI-1744; BI1744; STRIVERDI RESPIMAT)is a ultra-long acting beta-adrenoceptor agonist approved in 2014 for use as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD) It was developed and manufactured by Boehringer-Ingelheim. |
|
V27563 | Piclidenoson (CF-101) | 152918-18-8 | Piclidenoson, formerly known as CF101, is a specific agonist to the A3 adenosine receptor, which inhibits the development of colon carcinoma growth in cell cultures and xenograft murine models. |
|
V3944 | Preladenant (MK-3814; SCH420814) | 377727-87-2 | Preladenant (formerly known as MK-3814; SCH-420814) is a novel potent, selective and competitive antagonist of adenosine A2A receptor with potential immunomodulatory effects and may be used for the treatment for Parkinson's disease. |
|
V3125 | Proxyphylline | 603-00-9 | Proxyphylline is a derivative of methylxanthine that is clinically used as a cardiac stimulant, a vasodilator and a bronchodilator. |
|
V75261 | PSB 0777 ammonium | 2122196-16-9 | PSB 0777 ammonium is a potent and specific adenosine A2A receptor agonist/activator with Kis of 44.4 nM and 360 nM for rat and human A2A receptors respectively. |
|
V76587 | PSB 0777 ammonium hydrate | PSB 0777 ammonium hydrate is a potent and specific adenosine A2A receptor agonist/activator with Kis of 44.4 nM and 360 nM for rat and human A2A receptors respectively. | |
|
V75266 | PSB-10 hydrochloride | 591771-91-4 | PSB-10 HCl is a potent and specific human adenosine A3 receptor (A3AR) antagonist (inhibitor) with a Ki of 0.44 nM. |
|
V75260 | PSB-1901 | 2332835-02-4 | PSB-1901 is a potent A2B adenosine receptor (A2BAR) antagonist (inhibitor) with Kis of 0.0835 nM and 0.131 nM for human and mouse A2BAR, respectively. |
|
V75279 | PSB11 hydrochloride | 453591-58-7 | PSB11 HCl is an antagonist (inhibitor) with inverse agonistic activity of human A3 adenosine receptor and has high affinity (Ki=2.3 nM) to human A3 adenosine receptor. |
|
V5091 | Regadenoson (CVT-3146) | 313348-27-5 | Regadenoson (CVT3146), a novel and potent A2A adenosine receptor agonist, is a coronary vasodilator that is commonly used in pharmacologic stress testing. |
|
V81281 | Regadenoson-d3 (CVT-3146-d3) | Regadenoson-d3 is the deuterium labelled form of Regadenoson. | |
|
V0351 | Reversine | 656820-32-5 | Reversine is a cell-permeable, selective and ATP-competitive inhibitor of human A3 adenosine receptor and a pan-aurora A/B/C kinase inhibitor as well with potential anticancer activity. |
|
V2917 | SCH-58261 | 160098-96-4 | SCH-58261 (SCH58261; SCH 58261) is a novel, potent, selective and competitive antagonist of the adenosine A2A receptor with immunomodulatory and neuroprotective effects. |
|
V75272 | SDZ-WAG994 (WAG-994; N6-Cyclohexy-2'-0-methyladenosine) | 130714-47-5 | SDZ-WAG994 (WAG-994) is a stable, long-acting, selective, orally bioactive A1-adenosine receptor agonist/activator with a KD of 23 nM. |
|
V15215 | SR 59230A HCl | 1135278-41-9 | SR 59230A HCl is a potent, brain penetrant and selective β3 adrenoceptor antagonist with IC50 values of 40, 408 and 648 nM for β3, β1 and β2 receptors respectively. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
