Size | Price | Stock | Qty |
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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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Other Sizes |
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Purity: ≥98%
NBMPR( NBTI) is a nucleoside analog that competitively inhibits the equilibrative nucleoside transporter 1 (Kd = 0.1-1.0 nM, IC50s = 4.6 and 3.6 nM in rat and human, respectively). NBMPR is commonly used to selectively block nucleoside transport mediated by equilibrative nucleoside transporters 1 (ENT1) and 2 (ENT2), at concentrations of 0.10 μM and 0.10 mM, respectively. ABCG2 activity is eliminated by NBMPR at a concentration of 0.10 mM.
Targets |
ENT1 transporter
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References |
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Molecular Formula |
C17H17N5O6S
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Molecular Weight |
419.41178
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Exact Mass |
419.09
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Elemental Analysis |
C, 48.68; H, 4.09; N, 16.70; O, 22.89; S, 7.64
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CAS # |
38048-32-7
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Appearance |
Solid powder
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SMILES |
C1=CC(=CC=C1CSC2=NC=NC3=C2N=CN3[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)[N+](=O)[O-]
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InChi Key |
DYCJFJRCWPVDHY-LSCFUAHRSA-N
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InChi Code |
InChI=1S/C17H17N5O6S/c23-5-11-13(24)14(25)17(28-11)21-8-20-12-15(21)18-7-19-16(12)29-6-9-1-3-10(4-2-9)22(26)27/h1-4,7-8,11,13-14,17,23-25H,5-6H2/t11-,13-,14-,17-/m1/s1
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Chemical Name |
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[(4-nitrophenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diol
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Synonyms |
NSC-296962; NSC 296962; NSC296962; NBMPR; NBTI; S-4-nitrophenylmethyl-6-thioinosine
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: 50~84 mg/mL (119.2~200.3 mM)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.3843 mL | 11.9215 mL | 23.8430 mL | |
5 mM | 0.4769 mL | 2.3843 mL | 4.7686 mL | |
10 mM | 0.2384 mL | 1.1922 mL | 2.3843 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.