Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. Four AR subtypes have so far been cloned and found in various tissues. When exposed to agonists, these receptors exhibit unique localization, signal transduction pathways, and modes of regulation. The capacity of some Adenosine receptors to act as sensors of cellular oxidative stress, which is transmitted by transcription factors like NF-B to control the expression of ARs, is one of their key characteristics. We'll look at the role of adenosine receptors in the control of healthy and unhealthy processes, including sleep, the growth of cancer, and the prevention of hearing loss.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V13038 | Bopindolol Malonate | 82857-38-3 | Bopindolol Malonate (CTK-8F8315; LS-120081; HE-393689; D-01794) is a potent beta adrenoceptor antagonist with the potential to be used for essential and renovascular hypertension. |
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V4212 | Capadenoson | 544417-40-5 | Capadenoson (formerly also known as BAY 68-4986) is a novel, orally bioactive, potent and selective adenosine A1 receptor agonist. |
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V1482 | CGS 21680 HCl | 124431-80-7 | CGS 21680 HCl (CGS21680; CGS-21680), the hydrochloride salt of CGS 21680,is a potent and specific agonist of adenosine A2 receptors with potential antideppressant activity. |
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V3272 | Ciforadenant (CPI-444; V81444) | 1202402-40-1 | Ciforadenant (formerly known as CPI-444; V-81444)is a potent, selective and orally bioactive small molecule inhibitor of the adenosine-A2a receptor(A2AR) on T-lymphocytes with anticancer and immunomodulatory activities and the potential to be used in cancer immunotherapy. |
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V75270 | Danshenol B | 189308-09-6 | Danshenol B is a diterpenoid. |
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V41528 | DPCPX | 102146-07-6 | DPCPX (PD-116948; PD116948) is a xanthine derivative acting as a selective A1 adenosine receptor antagonist. |
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V75276 | DPTN dihydrochloride | 325767-87-1 | DPTN is a potent and specific antagonist of human, mouse and rat A3AR with Kis of 1.65, 9.61 and 8.53 nM respectively. |
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V11026 | Etrumadenant (AB928) | 2239273-34-6 | Etrumadenant (AB928; AB-928) is a first-in-class, clinical stage, oral and dual antagonist of the A2aR and A2bR adenosine receptors with potential anticancer and immunomodulatory activity. |
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V75277 | hA3ARagonist 1 | 2821704-65-6 | hA3AR agonist 1 is a potent human adenosine receptor (hA3AR) agonist with Ki of 2.40 nM. |
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V79766 | Heterobivalent ligand-1 | Heterobivalent ligand-1 (compound 26) is a heterobivalent ligand of the adenosine A 2A-dopamine D 2 receptor heteromer (KDB1 A2AR=2.1 nM, KDB1 D2R= 0.13 nM). | |
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V12840 | Idazoxan HCl | 79944-56-2 | Idazoxan HCl (RX781094A; RX-781094 hydrochloride) is a potent and selective α2 adrenergic receptor antagonist, and an antagonist for the imidazoline receptor. |
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V0069 | Imaradenant (AZD-4635; HTL1071) | 1321514-06-0 | Imaradenant (AZD4635; HTL-1071) is a novel, potent, selective, orally bioavailable small molecule inhibitor of the adenosine A2A receptor (A2AR) (Ki = 1.7 nM) with potential anticancer immunomodulatory activity. |
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V75259 | Inupadenant hydrochloride (EOS-850 hydrochloride) | 2411004-22-1 | Inupadenant (EOS-850) HCl is an orally bioactive, selective A2A receptor antagonist. |
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V1483 | Istradefylline (KW-6002) | 155270-99-8 | Istradefylline (formerly KW6002; KW 6002; KW-6002; Nourianz), a caffeine derivative, is an orally bioavailable and selective adenosine A2A receptor (A2AR) antagonist with anti-PD (Parkinson's disease) effects. |
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V25457 | Metipranolol hydrochloride | 36592-77-5 | Metipranolol is a potent non-selective beta blocker (β adrenergic receptorantagonist) used in eye drops to treat glaucoma. |
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V2492 | MIPS-521 | 1146188-19-3 | MIPS521 is a positive allosteric modulator (PAM) of the adenosine receptor (A1AR). |
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V75262 | MRS-3777 hemioxalate | 1186195-57-2 | MRS-3777 hemioxalate is a selective adenosine A3 receptor blocker (antagonist). |
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V11088 | MRS1754 | 264622-58-4 | RS1754 (MRS-1754; MRS 1754) is a novel, selective and potent A2B antagonist 2B antagonist with anticancer activity. |
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V80840 | MRS7935 | MRS7935 (compound 15) is an A1AR positive allosteric modulator (PAM) with EC50 of about 2 μM. | |
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V75264 | N6-Benzyl-5'-ethylcarboxamido adenosine | 152918-32-6 | N6-Benzyl-5'-ethylcarboxamido adenosine is a selective A3 adenosine receptor agonist (activator). |
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