Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. Four AR subtypes have so far been cloned and found in various tissues. When exposed to agonists, these receptors exhibit unique localization, signal transduction pathways, and modes of regulation. The capacity of some Adenosine receptors to act as sensors of cellular oxidative stress, which is transmitted by transcription factors like NF-B to control the expression of ARs, is one of their key characteristics. We'll look at the role of adenosine receptors in the control of healthy and unhealthy processes, including sleep, the growth of cancer, and the prevention of hearing loss.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V15521 | Sulmazole | 73384-60-8 | Sulmazole (Vardax; AR-L 115BS; AR-L 115-BS) is an A1 adenosine receptor antagonist that inhibits the function of guanine nucleotide regulatory proteins by affecting GTP turnover. |
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V15718 | Taminadenant | 1337962-47-6 | Taminadenant (PBF-509; NIR-178) is a novel, oral and potent adenosine receptor antagonist used as animmunotherapy agent. |
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V75267 | TC-G 1004 | 1061747-72-5 | TC-G 1004 (compound 16j) is an orally bioavailable A2A adenosine receptor antagonist (inhibitor) with Kis of 0.44 nM and 80 nM for hA2A and hA1, respectively. |
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V16089 | Terbutaline | 23031-25-6 | Terbutaline is a potent and selective β2-adrenergic receptor agonist with IC50 of 53 NM,it has little or no effect on alpha-adrenergic receptors. |
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V81591 | Ticlopidine-d4 hydrochloride (Ticlopidine d4 hydrochloride (hydrochloride)) | Ticlopidine-d4 ( HCl) is the deuterated form of Ticlopidine HCl. | |
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V16551 | Todralazine hydrochloride | 3778-76-5 | Todralazine HCl (Ecarazine HCl) is an anti-hypertensive (blood pressure lowering) agent, a β2 adrenergic receptor (β2AR) blocker, and has antioxidant and free radical scavenging activities. |
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V16631 | Tozadenant | 870070-55-6 | Tozadenant (formerly RO-4494351; SYN-115) is an orally bioavailable, selective adenosine A2A receptor antagonist with potential usefulness in the treatment of Parkinson disease (PD). |
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V3943 | VIPADENANT | 442908-10-3 | Vipadenant (formerly BIIB-014; CEB-4520; V-2006; VER-11135) is a novel potent, selective and orally bioactive antagonist of adenosine A2A receptor with immunomodulatory and antidegenerative effects. |
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V34663 | XAC 3HCL | 96865-92-8 | Xanthine amine congener is a nonselective adenosine receptor blocker (antagonist) that induces convulsions in mice. |
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V75265 | Xanthine amine congener dihydrochloride (XAC dihydrochloride) | 1962928-23-9 | Xanthine amine congener di-HCl (XAC di-HCl) is a potent adenosine A1 receptor and A2 receptor antagonist (inhibitor) with IC50s of 1.8 and 114 nM, respectively. |
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V10427 | ZM241385 | 139180-30-6 | ZM241385 is a potent, high-affinity and selective adenosine A2AR antagonist (inhibitor) with Ki of 1.4 nM. |
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