PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death.The PARP family consists of 17 individuals. They are all very different in terms of their cell structures and functions. There is confirmed PARP activity in the following proteins: PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2). Additional genes include PARP3, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. The nucleus of the cell contains PARP. The primary responsibility is to identify and alert the enzymatic machinery responsible for SSB repair to single-strand DNA breaks (SSB).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V121468 | (2S,3R,4S)-ASX-173 | 2748800-07-7 | (2S,3R,4S)-ASX-173 is the (2S,3R,4S)-enantiomer of ASX-173. |
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V122042 | (rac)-Talazoparib | 1207454-56-5 | (rac)-Talazoparib is an orally effective PARP1/2 inhibitor with Ki values of 1.2 nM and 0.87 nM, respectively. |
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V12600 | BGP-15 HCl | 66611-37-8 | BGP-15 HCl is a potent and novel PARP inhibitor that can protect against heart failure and atrial fibrillation in mice. |
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V51302 | 5-AIQ (5-Aminoisoquinolin-1-one) | 93117-08-9 | 5-AIQ (also known as 5-Aminoisoquinolin-1-one) is a water-soluble PARP-1 inhibitor. |
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V124819 | 2'-Nitroflavone | 53277-26-2 | 2'-Nitroflavone is a PARP1 inhibitor. |
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V52511 | 2-Methylquinazolin-4-ol (2-methyl-4(3H)-quinazolone) | 1769-24-0 | 2-Methylquinazolin-4-ol is a highly efficient and competitive poly(ADP-ribose) synthetase inhibitor with a Ki value of 1.1 μM. |
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V2572 | Picolinamide | 1452-77-3 | Picolinamide (2-Pyridinecarboxamide, Picolinoylamide, 2-Carbamoylpyridine)is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. |
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V124689 | 2H-Indazole-7-carboxamide | 952479-70-8 | 2H-Indazole-7-carboxamide is a PARP1 ligand that can be used to synthesize PROTACs, such as PROTAC PARP1 degrader-1. |
![3,4-二氢-2H-吡喃[3,2-b]吡啶-4-醇](http://www.invivochem.com/upload/1124/V51286.png)
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V51286 | DR-2313 | 284028-90-6 | DR2313 is a novel and brain-penetrant inhibitor of poly(ADP-ribose) polymerase (PARP), with IC50s of 0.20 μM and 0.24 μM for PARP-1 and PARP-2, respectively. |
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V0306 | PARP-IN-1 (3-aminobenzamide; 3-ABA; 3-AB) | 3544-24-9 | PARP-IN-1(3-Aminobenzamide; 3-ABA; 3-AB) is a novel and potent inhibitor of PARP [Poly(ADP-ribose)polymerase] with potential anticancer activity. |
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V51309 | 3-Methoxybenzamide (3-MBA) | 5813-86-5 | 3-Methoxybenzamide (3-MBA), an inhibitor of PARP and ADP-ribosyltransferase (ADPRTs) prevents Bacillus subtilis cells from dividing, which causes filamentation and ultimately cell lysis. |
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V88723 | 4F-DDC | 4F-DDC is a novel PARP1 inhibitor with an IC50 value of 82 nM. | |
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V106500 | 5-AIQ hydrochloride | 93117-07-8 | 5-AIQ hydrochloride is a water-soluble PARP-1 inhibitor. |
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V56026 | 6(5H)-Phenanthridinone | 1015-89-0 | 6(5H)-Phenanthridinone is a selective and novel PARP-1 inhibitor and immunomodulator. |
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V103018 | 8-Chloroquinazolin-4-ol | 101494-95-5 | 8-Chloroquinazolin-4-ol (Compd 18) is an inhibitor of PARP-1 enzyme with IC50 value of 5.65 μM. |
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V127776 | 8-ET-NAD+ sodium | 8-ET-NAD+ sodium is a derivative of NAD+. | |
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V115848 | A-620223 | 272769-49-0 | A-620223 is a PARP-1 inhibitor with a Ki value of 8 nM for PARP-1 and an EC50 value of 3 nM in whole-cell assays. |
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V0313 | A-966492 | 934162-61-5 | A-966492 is a selective andorally bioavailable PARP [poly(ADP-ribose) polymerase] inhibitor with potential anticancer activity. |
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V128337 | ADP-ribose/PARP-IN-1 | 3047557-92-3 | ADP-ribose/PARP-IN-1 is a coupling compound. |
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V0305 | AG-14361 | 328543-09-5 | AG14361 (AG-14361) is a novel, potent and selective inhibitor of poly (ADP-ribose) polymerase-1 (PARP1) with potential anticancer activity. |
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