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| Other Sizes |
| Targets |
CDP targets enzymes involved in nucleotide metabolism and phospholipid synthesis. It serves as a substrate for nucleoside diphosphate kinase in the synthesis of CTP. CDP is also a substrate for choline-phosphate cytidylyltransferase and ethanolamine-phosphate cytidylyltransferase in the synthesis of CDP-choline and CDP-ethanolamine, respectively, which are key intermediates in phospholipid biosynthesis.
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| ln Vitro |
CDP demonstrates in vitro activity as a substrate for various enzymes involved in nucleotide and phospholipid metabolism. It is used in enzymatic assays to measure the activity of nucleoside diphosphate kinase, choline-phosphate cytidylyltransferase, and ethanolamine-phosphate cytidylyltransferase. The compound's activity is assessed by its ability to support these enzymatic reactions.
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| ln Vivo |
For the diagnosis and investigation of CDP-l-ribitol pyrophosphorylase A (CRPPA) muscular dystrophy, CDP-ribitol can be utilized [3].
CDP is an endogenous nucleotide that is involved in nucleotide metabolism and phospholipid synthesis in vivo. It plays a role in the synthesis of CDP-choline and CDP-ethanolamine, which are essential for membrane phospholipid biosynthesis. CDP is also involved in the synthesis of CTP. |
| Enzyme Assay |
In vitro enzyme assays for CDP involve measuring its conversion to CTP by nucleoside diphosphate kinase, or its conversion to CDP-choline or CDP-ethanolamine by the respective cytidylyltransferases. The assays typically measure the formation of products using spectrophotometric, radiometric, or HPLC-based methods.
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| Cell Assay |
In vitro cellular assays for CDP are not typically performed, as the compound is a nucleotide used as a substrate in enzymatic assays. Its role in phospholipid synthesis can be studied in cell culture models by measuring the incorporation of labeled precursors into phospholipids.
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| Animal Protocol |
CDP is not typically administered in animal experiments as a therapeutic agent. It is an endogenous nucleotide that is involved in normal cellular metabolism. Its role in phospholipid synthesis makes it essential for cell membrane integrity and function.
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| ADME/Pharmacokinetics |
CDP is a naturally occurring nucleotide that is synthesized intracellularly. Its concentration is tightly regulated within cells. CDP is a precursor in the biosynthesis of CTP and is involved in phospholipid synthesis. The compound is used as a research reagent in biochemical assays.
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| Toxicity/Toxicokinetics |
CDP is a naturally occurring nucleotide and is not considered toxic at physiological concentrations. The compound is intended for research use only. Standard laboratory safety precautions should be followed when handling this compound.
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| References | |
| Additional Infomation |
Cytidine 5'-diphosphate trisodium salt (CDP) (CAS#: 34393-59-4) has the molecular formula C9H12N3O11P2·3Na and a molecular weight of 469.12. It is a nucleotide consisting of cytidine linked to two phosphate groups. CDP is involved in nucleotide metabolism and phospholipid synthesis. It is for research use only.
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| Exact Mass |
468.96
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|---|---|
| CAS # |
34393-59-4
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| Related CAS # |
Cytidine diphosphate;63-38-7
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| PubChem CID |
23519589
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| Appearance |
Off-white to light yellow solid powder
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| LogP |
0
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
11
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
28
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| Complexity |
671
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| Defined Atom Stereocenter Count |
4
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| InChi Key |
JENUKVZGXGULDX-LLWADOMFSA-K
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| InChi Code |
InChI=1S/C9H15N3O11P2.3Na/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1
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| Chemical Name |
trisodium;[[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] phosphate
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| Synonyms |
CDP; Cytidine 5'-diphosphate trisodium salt
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~250 mg/mL (~532.9 mM)
DMSO : < 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (213.17 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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