RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V81142 | PINT-87aa | PINT-87aa is an 87-amino acid (AA) peptide encoded by the circular form of the long intergenic nonprotein-coding RNA p53-induced transcript (LINC-PINT). | |
|
V81143 | PINT-87aa TFA | PINT-87aa TFA is an 87-amino acid (AA) peptide encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT). | |
|
V22437 | Plitidepsin | 137219-37-5 | Plitidepsin (dehydrodemnin B; aplidine; Aplidin) is a naturally occurring cyclic depsipeptide extracted from the marine tunicate Aplidium albicans with a broad spectrum of anticancer activities. |
|
V75900 | Pol I-IN-1 | 2765318-69-0 | Pol I-IN-1 is a potent inhibitor of RNA polymerase I (Pol I) with IC50 of 0.21 µM for the large Pol I catalytic subunit RPA194. |
|
V53287 | POL1-IN-1 | 1822358-25-7 | POL1-IN-1 is a RNA polymerase 1 POL1 (also known as Pol I) inhibitor with an IC50 value of less than 0.5 uM. |
|
V55159 | Poly(A) polymerase | 9026-30-6 | Poly(A) polymerase catalyzes the addition of a polyadenosine tail, or ATP, to the 3' end of RNA in the form of AMP. |
|
V75901 | Polynucleotide kinase | 37211-65-7 | Polynucleotide Kinase is a DNA repair enzyme. |
|
V81203 | Procaine-d4 hydrochloride (procaine d4 hydrochloride) | Procaine-d4 ( HCl) is the deuterated form of Procaine HCl. | |
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V1446 | Procarbazine HCl (NSC-77213) | 366-70-1 | Procarbazine HCl (formerly NSC77213; Ro4-6467;CB-400-497; PCB; PCZ; Matulane; Natulanar), the hydrochloride salt form of procarbazine, is ananticancer chemotherapeutic medication approved for the treatment of Hodgkins lymphoma and certain brain cancers. |
|
V55119 | Prunasin | 99-18-3 | Prunasin is an inhibitor (blocker/antagonist) of DNA Polymerase β. |
|
V1433 | Pyridostatin Trifluoroacetate (RR82) | 1472611-44-1 | Pyridostatin Trifluoroacetate(RR82; RR 82; RR-82; PDS; Pyridostatin TFA), the Trifluoroacetate(TFA) salt of Pyridostatin, is a G-quadruplexe stabilizer with potential antineoplastic activity. |
|
V80291 | qsl-304 | qsl-304 is a DNA gyrase B inhibitor. | |
|
V34728 | Quinizarin (1,4-Dihydroxyanthraquinone; 1,4-Dihydroxyanthraquinone) | 81-64-1 | Quinizarin (1,4-Dihydroxyanthraquinone) is a part of anti-cancer active molecules such as Doxorubicin, Daunorubicin, Adriamycin, etc. |
|
V1473 | Raltitrexed (ZD1694） | 112887-68-0 | Raltitrexed (formerly Thaltitrexed; ICID1694; TDX; ZD-1694; D1694; ICI-D1694; trade name: Tomudex),a quinazoline folate analog, is an approved antimetabolite anticancer drug used in cancer chemotherapy for treating colorectal cancer and malignant mesothelioma. |
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V81278 | RdRP-IN-6 | RdRP-IN-6 (compound 27) inhibits RNA dependent-RNA polymerase (RdRp) with an IC90 value of 14.1 μM. | |
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V4300 | Remdesivir (GS-5734) | 1809249-37-3 | Remdesivir (GS-5734; Veklury) is an FDA approved drug for the treatment of 2019-nCoV (COVID-19 pandemic, CoronaVirus) infections requiring hospitalization. |
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V2203 | Remdesivir O-desphosphate acetonide impurity | 1191237-80-5 | Remdesivir O-desphosphate acetonide impurity is a Remdesivirimpurity and an important intermediate to synthesize antiviral drug remdesivir. |
|
V4489 | RG3039 | 1005504-62-0 | RG3039 (also known as PF-06687859; PF 06687859), a member of a chemical series that was identified and optimized using an SMN2 promoter screen, is a novel, potent, orally bioavailable and brain-penetrant DcpS (decapping scavenger enzyme) inhibitor with an IC50 of 0.069 nM. |
|
V5680 | RG7800 | 1449598-06-4 | RG7800 (also known as RG-7800; RO6885247) is a potent and selective survival motor neuron 2 (SMN2) splicing modifier, which is currently being studies in human clinical trials for the treatment of Spinal Muscular Atrophy (SMA). |
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V76558 | RG7800 tetrahydrochloride (RO6885247 tetrahydrochloride) | RG7800 HCl is an orally bioavailable SMN2 splicing modulator with EC1.5x values of 23 nM and 87 nM for SMN2 splicing and SMN protein, respectively. |
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