Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptor superfamily ligand-activated transcription factors that include the following three subtypes: PPAR, PPAR, and PPAR/. Higher organisms' cellular differentiation, development, metabolism (carbohydrate, lipid, and protein), as well as tumorigenesis, are all crucially regulated by PPARs. All PPARs bind to particular regions of the target genes' DNA through heterodimerization with the retinoid X receptor (RXR). Triglyceride levels are reduced and energy homeostasis is regulated when PPAR- is activated. PPAR- activation improves the metabolism of glucose, whereas PPAR-/ activation improves the metabolism of fatty acids.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V60007 | GW-590735 | 343321-96-0 | GW 590735 is a potent and specific PPARα agonist. |
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V4928 | GW-7647 | 265129-71-3 | GW7647 (GW-7647) is a novel, selective and potent agonist of human and murine PPARα4 with EC50s of 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ and PPARδ, respectively. |
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V4936 | GW1929 | 196808-24-9 | GW1929 is a novel, potent and selective PPAR-γ agonist with a pKi of 8.84 for human PPAR-γ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively. |
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V51335 | GW9662-d5 | 2117730-84-2 | GW9662-d5, deuterium labeled GW9662. GW9662 is a novel antagonist of PPARγ that exhibits selectivity over PPARα and PPARδ of 10 and 1000 times, respectively, at an IC50 of 3.3 nM. |
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V5144 | Indeglitazar (PPM 204 and PLX 204) | 835619-41-5 | Indeglitazar (formerly PPM-204 and PLX-204) is a novel, potent and orally bioavailable peroxisome proliferator-activated receptor (PPAR) pan-agonist for all three PPAR subtypes alpha (α), delta (δ) and gamma (γ). |
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V67759 | KD-3010 | 934760-92-6 | KD-3010 is an orally bioactive, potent and specific PPARδ agonist. |
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V3029 | Lanifibranor | 927961-18-0 | Lanifibranor (formerly named as IVA-337) is a novel, potent and well balanced agonist of the pan-peroxisome proliferator-activated receptors (PPAR) with excellent safetyprofiles and with EC50s of 1.5, 0.87 and 0.21 μM for human PPARα, PPARσ and PPARγ, respectively. |
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V31420 | LJ570 | 2252488-69-8 | LJ570 is a dual PPARα/PPARγ agonist with EC50 of 1.05 and 0.12 μM. |
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V24880 | MA-0204 | 2095128-17-7 | MA-0204 is a highly potent and selective PPARd modulator (PPARδ EC50 = 0.4 nM; PPARalpha, EC50 == 6,660 nM) that upregulates the expression of FAO genes in human renal proximal tubule cells, resulting in increased mitochondrial fatty acid oxidation. |
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V51328 | Mavodelpar sodium (REN-001; HPP-593) | 1604815-32-8 | Mavodelpar (REN001) is a novel and potent agonist of PPARδ. |
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V51350 | Mesalamine impurity P | 887256-40-8 | Mesalamine impurity P is a mesalamine impurity . |
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V51346 | Methyl oleanonate | 1721-58-0 | Methyl oleanonate is a naturally occurring triterpene PPARγ agonist that was isolated from the Pistacia lentiscus var. Chia species. |
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V51352 | MSDC-0602K (Azemiglitazone potassium) | 1314533-27-1 | MSDC-0602K(Azemiglitazone potassium) is a thiazolidinedione (Ps-TZD) that spares PPARγ; its IC50 value is 18.25 μM. |
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V3520 | Muraglitazar (BMS298585) | 331741-94-7 | Muraglitazar (BMS-298585; BMS298585) is a novel, potent and selective Peroxime Proliferator Activated (PPAR) α/γ dual agonist with glucose- and lipid-lowering activities. |
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V51344 | Oleoyl Ethanolamide-d2 | 1245477-09-1 | Oleoylethanolamide-d2 is the labeled Oleoylethanolamide, deuterium. |
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V56571 | Palmitelaidic acid-d13 (palmitate d13) | 2692623-91-7 | Palmitelaidic acid-d13 is the deuterated form of Palmitelaidic Acid. |
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V51336 | Pioglitazone-d4 (alkyl) | 1134163-31-7 | Pioglitazone-d4 (alkyl) (U 72107-d4 (alkyl)), deuterium labeled Pioglitazone. |
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V51327 | PPARα/γ agonist 2 | 2213365-56-9 | PPARα/γ agonist 2 is a novel and potent PPARα full agonist and PPARγ partial agonist. |
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V67758 | PPARαagonist 1 | 2361366-85-8 | PPARα agonist 1 is a potent, complete PPARα agonist. |
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V67760 | PPARγ agonist 8 | 1049800-41-0 | PPARγ agonist 8 is an agonist of PPARγ. |
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