Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptor superfamily ligand-activated transcription factors that include the following three subtypes: PPAR, PPAR, and PPAR/. Higher organisms' cellular differentiation, development, metabolism (carbohydrate, lipid, and protein), as well as tumorigenesis, are all crucially regulated by PPARs. All PPARs bind to particular regions of the target genes' DNA through heterodimerization with the retinoid X receptor (RXR). Triglyceride levels are reduced and energy homeostasis is regulated when PPAR- is activated. PPAR- activation improves the metabolism of glucose, whereas PPAR-/ activation improves the metabolism of fatty acids.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V67762 | PPARγ phosphorylation inhibitor 1 | 2882975-84-8 | PPARγ phosphorylation inhibitor 1 (Compound 10) is a potent PPARγ binder with IC50 of 24 nM. |
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V67763 | PPARγ-IN-2 | 2682078-97-1 | PPARγ-IN-2 (Compound 5a) is a PPARγ inhibitor. |
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V80219 | PPARγ/GR modulator 1 | PPARγ/GR modulator 1 is an orally bioactive dual-action agonist of PPARγ and glucocorticoid receptor (GR) with Kis of 3.3 and 33.6 μM, respectively. | |
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V79264 | Pparδagonist 5 | Pparδ agonist 5, an orally bioactive and selective PPARδ agonist (EC50=0.335 μM), is more selective than GW0742. | |
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V67764 | PPARδagonist 9 | 928023-21-6 | PPARδ agonist 9 (compound 21) is a PPARδ agonist (EC50= 3.6 nM). |
|
V2428 | PTGR2-IN-1 | 349093-44-3 | PTGR2-IN-1 is a potent PTGR2 inhibitor (IC50 = 0.7 μM) that can increase 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells. |
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V54440 | Rivoglitazone (R-106056) | 185428-18-6 | Rivoglitazone is a thiazolidinedione analogue and agonist of PPARγ utilized in study/research of type 2 diabetes. |
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V14589 | Seladelpar (MBX8025, RWJ800025) | 851528-79-5 | Seladelpar (formerly MBX-8025 and RWJ-800025) is a novel,orally bioactive and selective peroxisome proliferator-activated receptor (PPAR)-δ receptor agonist with anti-cholestatic effects. |
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V76523 | Seladelpar sodium salt (MBX-8025 sodium salt; RWJ-800025 sodium salt) | Seladelpar sodium salt (MBX-8025) is an orally bioactive, selective PPARδ agonist/activator with EC50 of 2 nM. | |
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V79573 | SP4e | SP4e is an activator of PPAR-γ with EC50 of 739 nM in HK-2 cells. | |
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V79574 | SP4f | SP4f is an activator of PPAR-γ with EC50 of 826 nM in HK-2 cells. | |
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V3521 | Tesaglitazar | 251565-85-2 | Tesaglitazar (also known as AZ-242; Galida;AR-H-039242XX) is a dual peroxisome proliferator-activated receptor (PPAR) agonist with anti-diabetic effects. |
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V51366 | Tibesaikosaponin V (TKV) | 2319668-87-4 | Tibesaikosaponin V (also known as TKV) is a triterpene diglycoside that can be separated from the Bupleurum chinense DC roots' methanol extract. Without harming adipocytes, tibesaikosaponin V prevents lipid buildup and triacylglycerol content. |
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V32180 | VCE-004.8 | 1818428-24-8 | VCE-004.8, a semi-synthetic multitarget cannabinoquinoid, is a specific PPARγ and CB2 receptor dual agonist with potent anti-inflammatory activity. |
|
V51334 | Wistin | 19046-26-5 | Wistin is extracted from the roots of Caragana sinica and is an agonist of PPARα and PPARγ. |
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