Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptor superfamily ligand-activated transcription factors that include the following three subtypes: PPAR, PPAR, and PPAR/. Higher organisms' cellular differentiation, development, metabolism (carbohydrate, lipid, and protein), as well as tumorigenesis, are all crucially regulated by PPARs. All PPARs bind to particular regions of the target genes' DNA through heterodimerization with the retinoid X receptor (RXR). Triglyceride levels are reduced and energy homeostasis is regulated when PPAR- is activated. PPAR- activation improves the metabolism of glucose, whereas PPAR-/ activation improves the metabolism of fatty acids.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V54369 | Ciprofibrate impurity A | 1474058-89-3 | Ciprofibrate impurity A is an impurity in Ciprofibrate. |
|
V18511 | Clofibrate | 637-07-0 | Clofibrate (Atromid-S)is a novel and potent lipid-lowering agent acting as anagonist of PPAR with EC50s of 50 μM, ∼500 μM for murine PPARα and PPARγ, and 55 μM, ∼500 μM for human PPARα and PPARγ, respectively. |
|
V51331 | Clofibrate-d4 | 1189654-03-2 | Clofibrate-d4, deuterium labeled Clofibrate. |
|
V51349 | Clofibric acid-d4 (Chlorofibrinic acid-d4) | 184991-14-7 | Clofibric acid-d4 (Chlorofibrinic acid-d4), deuterium labeled Clofibric acid. |
|
V52604 | Clofibric acid-d4 (Chlorofibric acid-d4) | 1184991-14-7 | Clofibric acid-d4 is the deuterated form of Clofibric acid. |
|
V54370 | CRX000227 | 686769-92-6 | CRX000227 is a PPAR modulator. |
|
V2124 | Daidzein | 486-66-8 | Daidzein is a naturally occuring isoflavone phytoestrogen isolated from Leguminosae, used as a component of foods and dietary supplements. |
|
V51341 | Daidzein-d4 | 1219803-57-2 | Daidzein-d4 is the deuterium labelled form of Daidzein. |
|
V51339 | DS-6930 | 1242328-82-0 | DS-6930 is a novel agonist of PPARγ, with an EC50 of 41 nM. DS-6930 has the potential to significantly lower plasma glucose (PG) while having fewer negative effects related to PPARγ than Rosiglitazone. |
|
V52152 | DSO-5a | 2195411-63-1 | DSO-5a is a specific, orally bioactive BB3 agonist. |
|
V3186 | Elafibranor | 923978-27-2 | Elafibranor (formerly GFT505) is a dual agonist of the PPARα/δ (peroxisome proliferator-activated receptor-α and -δ) with EC50 values of 45 and 175 nM, respectively. |
|
V51333 | Fenofibric acid-d6 | 1092484-69-9 | Fenofibric acid-d6 (FNF acid-d6), deuterium labeled Fenofibric acid. |
|
V55720 | Foenumoside B | 877661-00-2 | Foenumoside B is a triterpene saponin extracted from Lysimachia foenum-graecum. |
|
V54438 | FTX-6746 | 2829349-96-2 | FTX-6746 is an orally bioactive PPARG inhibitor. |
(%3dO)C1%3dC(C%3dC(C%3dC1)C%23N)C2%3dCC(%3dO)C3%3dC(N2)C%3dC(C%3dC3F)F)
|
V51061 | FX-909 | FX-909 is an inverse agonist of the covalent peroxisome proliferator-activated receptor gamma (PPARG). | |
|
V67761 | FX-909 | 2924573-90-8 | FX-909 is a covalent peroxisome proliferator-activated receptor gamma (PPARG) inverse agonist. |
|
V54439 | Gancaonin L | 129145-50-2 | Gancaonin L is an isoflavone extracted from Glycyrrhiza glabra. |
|
V52622 | Gemfibrozil-d6 (CI-719-d6) | 1184986-45-5 | Gemfibrozil-d6 is the deuterium labelled form of Gemfibrozil. |
|
V3035 | GSK0660 | 1014691-61-2 | GSK0660 is a potent and selective antagonist of PPARβ and PPARδ with IC50values of both 155 nM, it has little or no activity on PPARα and PPARγ with IC50values of >10 μM. |
|
V3544 | GW 501516 | 317318-70-0 | GW 501516 (also known as endurobol; GW-501516; GSK-516) is a novel and potent PPARδ agonist with an EC50 of 1.1 nM. |
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