Microtubules are a component of the cytoskeleton, found throughout the cytoplasm.These highly dynamic tubular tubulin polymers have an average length of 25 m and a maximum growth length of 50 micrometers. A microtubule has an inner diameter of 12 nm and an outer diameter of about 24 nm. Alpha and beta tubulin combine to form a dimer, which is then polymerized to form microtubules, which are found in eukaryotic cells. One of many members of a small family of globular proteins is tubulin.The alpha-, beta-, gamma-, delta-, and epsilon-tubulins are among the five distinct families that make up the tubulin superfamily, and a sixth family is only found in kinetoplastid protozoa. The proteins that make up microtubules, -tubulin and -tubulin, are the most prevalent members of the tubulin family. Microtubules play a crucial role in many cellular processes. They assist in keeping the cell's structure intact.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V79334 | Eribulin-d3 mesylate (Eribulin-d3 mesylate) | Eribulin-d3 (mesylate) is the deuterated form of Eribulin mesylate. | |
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V55259 | Ganoderic acid TQ (Ganodermic acid TQ) | 112430-66-7 | Ganoderic acid TQ (Ganodermic acid TQ) (compound 1) is a naturally occurring compound found in Ganoderma lucidum. |
|
V52055 | Glembatumumab vedotin (CDX-011; CR011-vcMMAE) | 1182215-65-1 | Glembatumumab vedotin (CDX-011) is an ADC (Antibody-Drug Conjugates (ADCs)) that contains a fully human IgG2 monoclonal antibody (mAb) (CR011) directed against glycoprotein NMB (GPNMB) and is combined with a potent Tubulin-binding cytotoxic agent MMAE conjugation. |
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V52054 | Glochidiol | 6610-56-6 | Glochidiol is an orally bioactive tubulin polymerization inhibitor (antagonist) with IC50 of 2.76 μM. |
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V85145 | GM-90257 | 315703-81-2 | |
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V2891 | HA15 | 1609402-14-3 | HA15 (HA-15) is aninhibitor of chaperone BiP (Binding immunoglobulin protein, GRP78) with anticancer activity. |
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V22543 | Indibulin | 204205-90-3 | Indibulin is a synthetic small molecule with antimitotic and potential antineoplastic activities. |
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V84602 | IR820-PTX | 2250419-19-1 | |
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V3514 | Ixabepilone | 219989-84-1 | Ixabepilone (formerly known as azaepothilone B and BMS-247550; Trade name: Ixempra)is a potent and orally bioavailable microtubule-stabilizing agent for the treatment of cancer. |
|
V79177 | KGP591 | KGP591 is a tubulin polymerization inhibitor (IC50 0.57µM). | |
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V53033 | KIF18A-IN-1 | 2600559-12-2 | KIF18A-IN-1 is an inhibitor (blocker/antagonist) of the mitotic kinesin KIF18A and has anti-tumor activity. |
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V51902 | KIF18A-IN-6 | 2914879-10-8 | KIF18A-IN-6 (Compound 134) is an orally bioactive KIF18A inhibitor that can suppress KIF18A microtubule-dependent ATPase activity with IC50 of 0.016 μM. |
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V51901 | KIF18A-IN-7 | 2914878-00-3 | KIF18A-IN-7 (Compound 22) is an orally bioactive KIF18A inhibitor that can suppress KIF18A microtubule-dependent ATPase activity with IC50 of 9.4 nM. |
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V24428 | LP-261 | 915412-67-8 | LP-261 is a novel and potent mitotic/tubulin inhibitor with potential anticaner activities. |
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V51814 | MAP4343 | 511-26-2 | MAP4343 is the 3-methyl ether analogue of Pregnenolone. |
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V25075 | Maytansine | 35846-53-8 | Maytansine (maitansine; NSC153858) is a cytotoxic antitubulin agent and an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. |
|
V6371 | Maytansinol | 57103-68-1 | Maytansinol (formerly also known as NSC-239386; Ansamitocin P-0), is a potent and natural microtubule depolymerizing agent or antimitotic agent with anticancer activity. |
|
V4654 | Mc-MMAE | 863971-24-8 | Mc-MMAE is a novel protective group for MMAE [(maleimidocaproyl)-conjugated monomethyl auristatin E], which is a highly potent mitotic/tubulininhibitor, and is a toxin payload/warhead in antibody drug conjugate (ADC). |
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V75824 | Microtubule destabilizing agent-1 | 2850370-28-2 | Microtubule destabilizing agent-1 (Compound 12b) is a hydroxamic acid-based microtubule destabilizing agent (MDA). |
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V85442 | Microtubule inhibitor 8 | 2310293-81-1 |
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