Microtubules are a component of the cytoskeleton, found throughout the cytoplasm.These highly dynamic tubular tubulin polymers have an average length of 25 m and a maximum growth length of 50 micrometers. A microtubule has an inner diameter of 12 nm and an outer diameter of about 24 nm. Alpha and beta tubulin combine to form a dimer, which is then polymerized to form microtubules, which are found in eukaryotic cells. One of many members of a small family of globular proteins is tubulin.The alpha-, beta-, gamma-, delta-, and epsilon-tubulins are among the five distinct families that make up the tubulin superfamily, and a sixth family is only found in kinetoplastid protozoa. The proteins that make up microtubules, -tubulin and -tubulin, are the most prevalent members of the tubulin family. Microtubules play a crucial role in many cellular processes. They assist in keeping the cell's structure intact.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V1887 | Monomethyl auristatin E (MMAE) | 474645-27-7 | Monomethyl auristatin E (also known as MMAE; SGD-1010), adolastatin 10 derivative, is a novel, synthetic and potent antimitotic/antitubulin agent which blocks the polymerization of tubulin,due to its high toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. |
C%3dC(O2)C3%3dCC%3dCC%3dC3CNC(%3dO)C4%3dCC5%3dC(N4)N%3dCS5)
|
V51064 | MP-HJ-1b | MP-HJ-1b is a novel tubulin inhibitor. | |
|
V26089 | Myoseverin | 267402-71-1 | Myoseverin is a reversible fission inducer of multinucleated myotubes into mononucleated fragments. |
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V41112 | Neuroinflammatory-IN-3 | 1202404-23-6 | Neuroinflammatory-IN-3 is a tubulin inhibitor and an anti-neuroinflammatory agent. |
|
V26884 | Ombrabulin HCl | 253426-24-3 | Ombrabulin HCl (AV-E8062;AC-7700;AVE8062), an analogue of combretastatin A4 with improved water solubility, is a novel and potent tubulin inhibitor andvascular-disrupting agent with anticancer activity. |
|
V55256 | P34cdc2 Kinase Fragment | 309247-52-7 | The P34cdc2 Kinase Fragment is associated with the integrity of DNA replication in yeast mitosis. |
|
V4474 | PF-06380101 | 1436391-86-4 | PF-06380101 (Auristatin 0101; PF06380101; AUR-0101) is a novel and ultra-potent cytotoxic Dolastatin 10 analogue and a tubulin inhibitor with excellent anticancer activity. |
|
V76638 | PF-06380101-d8 (Aur0101-d8; Auristatin-0101-d8) | PF-06380101-d8 is the deuterium labelled form of PF-06380101. | |
|
V83232 | PM-534 | 2446376-25-4 | PM-534 is a novel and potent inhibitor of tubulin assembly. |
|
V40995 | PM050489 | 960210-97-3 | PM050489 is a potent polyketide microtubule/tubulin inhibitor extracted from the Madagascar sponge Lithoplocamia lithistoides. |
|
V79576 | Podofilox-d6 (podophyllotoxin-d6) | Podofilox-d6 is the deuterium labelled form of Podofilox. | |
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V60090 | Podophyllotoxone | 477-49-6 | Podophyllotoxone is extracted from the roots of Illustrations anise and has anti-cancer effect. |
|
V37753 | S516 | 1016543-77-3 | S516 (Compound 22) is the bioactive metabolite of CKD-516 and a potent tubulin polymerization inhibitor (antagonist) with IC50 of 4.29 μM. |
|
V37480 | SB26019 | 1233078-90-4 | SB26019 is a potent anti-neuroinflammatory agent. |
|
V35266 | Sovilnesib (AMG 650) | 2410796-79-9 | Sovilnesib (AMG 650) is an orally bioavailable inhibitor of kinesin-like protein KIF18A with IC50 of 0.071 μM. |
|
V3749 | SSE15206 | 1370046-40-4 | SSE15206 is a mitotic inhibitor, specifically, a microtubule depolymerizing agent that can overcome multidrug resistance. |
|
V79817 | SSE1806 | SSE1806 is an analogue of podophyllotoxin (a natural antimitotic agent) and a microtubule/tubulin inhibitor (antagonist) with significant anticancer and antiproliferation activities. | |
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V55252 | Sudocetaxel | 1234218-62-2 | Sudocetaxel is a microtubule depolymerization inhibitor for pH-sensitive docetaxel release. |
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V54251 | T-peptide | 2022956-62-1 | T-peptide is a Tuftsin analog that may be utilized to study human immunodeficiency virus (HIV) infection. |
|
V75811 | Taccalonolide AJ | 2230777-09-8 | Taccalonolide AJ is a semi-synthetic compound with cellular microtubule stabilizing activity. |
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