New6

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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New6

New6 related products

Cat No.	Product Name	CAS No.	Product Description
V5280	24, 25-Dihydroxy Vitamin D3	40013-87-4	24, 25-Dihydroxy Vitamin D3 (24, 25-Dihydroxy D3; 24, 25-Dihydroxy VD3) is a vitamin D3 analog with important biological activities (anticancer, antiinflammatory et al.
V4404	ABT-670	630119-43-6	ABT-670 is a novel, potent, selective, orally bioavailable agonist ofdopamine D4receptorwithEC50of 89 nM, 160 nM, and 93 nM for human D4, ferret D4, and rat D4, respectively.
V4701	BI-689648	1633009-87-6	BI 689648 is a novel, potent and highly selectivealdosterone synthase (AS)inhibitor that can attenuate the production of aldosterone directly and has been proposed as an alternative to mineralocorticoid receptor antagonists for blocking the pathologic effects of excess aldosterone.
V4498	BMS 433771	543700-68-1	BMS 433771 is a novel and potent inhibitor of RSV (respiratory syncytial virus) replication in vitro.
V5229	CDD3505	173865-33-3	CDD3505 is a novel HDL cholesterol level inducing compound used for elevating high density lipoprotein cholesterol (HDL) by inducing hepaticcytochrome P450IIIA (CYP3A)activity.
V4490	CE-224535	724424-43-5	CE-224535 is anovel and selective P2X7 receptor antagonist that can be potentially used for the treatment of rheumatoid arthritis and osteoarthritis.
V4439	cFMS Receptor Inhibitor III	959861-21-3	cFMS Receptor Inhibitor III is a novel, potent and cell-permeable anilinoquinoline compound that acts as a strong, active site-targeting inhibitor of M-CSF/c-Fms-CSF-1R (MCSF receptor/cFMS) with IC50of 8 nM.
V5269	CP 375	752186-89-3	CP 375 is a novel and potent Fe3+chelating agent with a log K1value of 14.50 and with the absolute deviation between the predicted and experimental values of 0.12 (14.62 vs.
V5273	CP-10	2366268-80-4	CP-10 (CP10; CP 10), designed from a focused PROTAC library hijacking cancer therapeutic target CDK6, is a novel and potent PROTAC-based protein degrader targeting CDK6 with high selectivity, specificity, and remarkable CDK6 degradation efficiency (DC50=2.1 nM).
V5271	CP-28888 (CP 28888-27)	69938-75-6	CP-28888 (CP-28,888-27) is a novel and potent interferon inducer, it is more potent in mice, but is less active in man and devoid of antirhinovirus effects.
V5270	CP-316311	175139-41-0	CP 316311 is a novel, potent, selective and orally bioactive antagonist of the corticotropin-releasing factor 1 (CRF 1) receptor with anIC50value of 6.8 nM.
V5207	CP-409092 HCl	225240-86-8	CP-409092 HCl, the hydrochloride salt ofCP-409092, is a novel and potent partial agonist ofGABAAreceptorwith potential anti-anxiety activity.
V5299	CP-96486	139401-45-9	CP-96486 is a novel, potent and orally bioavailable antagonist of leukotriene D4(LTD4)/platelet activating factor (PAF) receptor withKis of 20 and 24 nM, respectively.
V4491	Dagrocorat	1044535-52-5	Dagrocorat (also known as PF-00251802) is a novel and potentdissociated glucocorticoid receptoragonist with thepotential usefulness as an anti-inflammatory agent.
V5265	DPQ	129075-73-6	DPQ (also known as PARP Inhibitor III) is a novel and potent inhibitor of PARPs [The poly(ADP-ribose) polymerases] which inhibits PARP1 activity with an IC50value of 40 nM.
V4487	Edotecarin	174402-32-5	Edotecarin (formerly ED-749; J-107088; J 107088; PF 804950) is a novel and potent inhibitor oftopoisomerase Ithat can induces single-strand DNA cleavage withIC50of 50 nM.
V5256	Elenbecestat (E2609)	1388149-39-0	Elenbecestat (E-2609; E2609) is a novel, potent orally bioactive and BBB-penetrantBACE1 inhibitor which can reduce the plasma beta-amyloid levels after single dosing and has the potential for the treatment of Alzheimers disease (AD).
V4492	Fosdagrocorat	1044535-58-1	Fosdagrocorat (formerly known as PF-04171327) is a phosphate ester prodrug of PF-00251802 (dagrocorat), a selective high-affinity partial agonist of the glucocorticoid receptor, which is further metabolized to PF-04015475.
V4485	Gosogliptin	869490-23-3	Gosogliptin (formerly also known as PF-734200 and PF-00734200) is a novel, potent and selective inhibitor ofdipeptidyl peptidase-IV(DPP-IV).
V5310	Lanraplenib (GS-9876)	1800046-95-0	Lanraplenib (also known as GS-9876; GS-SYK) is a highly selective and orally bioavailable Spleen Tyrosine Kinase (SYK) inhibitor with IC50of 9.5 nM).