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    ABT-670
    ABT-670

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4404
    CAS #: 630119-43-6Purity ≥98%

    Description: ABT-670 is a novel, potent, selective, orally bioavailable agonist of dopamine D4 receptor with EC50 of 89 nM, 160 nM, and 93 nM for human D4, ferret D4, and rat D4, respectively. It was discovered from a study aiming to identify a structurally distinct D(4)-selective agonist with superior oral bioavailability to the first-generation clinical candidate 1a (ABT-724) for the potential treatment of erectile dysfunction. Arylpiperazines such as (heteroarylmethyl)piperazine 1a, benzamide 2, and acetamides such as 3a,b exhibit poor oral bioavailability. Structure-activity relationship (SAR) studies with the arylpiperidine template provided potent partial agonists such as 4d and 5k that demonstrated no improvement in oral bioavailability. Further optimization with the (N-oxy-2-pyridinyl)piperidine template led to the discovery of compound 6b (ABT-670), which exhibited excellent oral bioavailability in rat, dog, and monkey (68%, 85%, and 91%, respectively) with comparable efficacy, safety, and tolerability to 1a. The N-oxy-2-pyridinyl moiety not only provided the structural motif required for agonist function but also reduced metabolism rates. 

    References: J Med Chem. 2006 Dec 14;49(25):7450-65.


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    ABT-670

    Name: ABT-670
    CAS#: 630119-43-6
    Chemical Formula: C19H21N3O2
    Exact Mass: 323.16338
    Molecular Weight: 323.39
    Elemental Analysis: C, 70.57; H, 6.55; N, 12.99; O, 9.89
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: ABT-670; ABT 670; ABT670
    IUPAC/Chemical Name: 3-Methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridine)-1'-ylmethyl)benzamide
    InChi Key: PUMMPCXNEPHBNN-UHFFFAOYSA-N
    InChi Code: InChI=1S/C19H23N3O2/c1-15-5-4-6-17(13-15)19(23)20-14-21-11-8-16(9-12-21)18-7-2-3-10-22(18)24/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,20,23)
    SMILES Code: Cc1cccc(c1)C(=O)NCN2CCC(CC2)c3cccc[n+]3[O-]


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