One of the main downstream targets of the PtdIns(3,4,5)P3 signaling pathway is the serine/threonine protein kinase Akt/PKB (Protein Kinase B), which has antiapoptotic activity. It has a pleckstrin homology (PH) domain that binds PtdIns(3,4,5)P3 on the plasma membrane in a particular way. The amount of PtdIns(3,4,5)P3 on the plasma membrane, which is controlled by PI3K, directly affects Akt phosphorylation and activation.
There are three isoforms of Akt: PKB/Akt1, PKB/Akt2, and PKB/Akt3. The PH (pleckstrin homology) domain and the kinase domain of the Akt isoforms are separated by a 39-amino-acid hinge region. Numerous substrates involved in cell survival, growth, proliferation, metabolism, and protein synthesis are controlled by catalytically active Akt.
A key mediator of cell survival, Akt, is deactivated in a number of diseases that involve pathological cell death brought on by stress.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70215 | TAT-TCL1-Akt-in | 1073630-46-2 | TAT-TCL1-Akt-in is an Akt inhibitor. |
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V70210 | TCL1(10-24) | 835655-37-3 | TCL1(10-24) is the betaA chain of human TCL1. |
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V0172 | TIC10 (imipridone, ONC201, NSC350625) | 1616632-77-9 | TIC10(ONC-201, NSC-350625), an imipridone compound,isa novel, potent, orally bioavailable, brain/BBB penetrant, and stable tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)inducer with potential anticancer activity. |
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V0168 | TIC10 Analogue (ONC-201 isomer) | 41276-02-2 | TIC10 Analogue (ONC201 isomer) is an analog/isomer of TIC10 and the inactive form of TIC10. |
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V92050 | Wortmannin-Rapamycin Conjugate 1 | 1067892-47-0 | Wortmannin-Rapamycin Conjugate 1 (compound 7c) is a furan ring-opened derivative of wortmanning-rapamycin conjugate with strong antitumor activity and good water solubility. |
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V3410 | YS 49 | 132836-42-1 | YS-49 (YS49) is a novel and potent anti-inflammatory agent and activator of PI3K/Akt signaling with the potential to be used for treating vascular diseases such as hypertension and atherosclerosis. |
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V70197 | ZINC00640089 | 667880-11-7 | ZINC00640089 is a specific lipocalin-2 (LCN2) inhibitor. |
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V87887 | α-Linolenic acid sodium | 822-18-4 | α-Linolenic acid sodium is an essential fatty acid isolated from Perilla frutescens that cannot be synthesized by the human body. |
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V19575 | Esculetin | 305-01-1 | Esculetin is a naturally occuring β-catenin inhibitor found mainly in chicory and other plant sources with antioxidant, antiinflammatory, and antitumor activities. |
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V3838 | Uprosertib (GSK2141795) | 1047634-65-0 | Uprosertib (formerly known as GSK2141795 and GSK795), an analog ofGSK2110183, is a potent, orally bioavailable andATP-competitive Akt inhibitor with IC50 values of 180 nM, 328 nM, and 38 nM for Akt1/Akt2/Akt3, respectively. |
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V18788 | Crebanine | 25127-29-1 | Crebanine is a novel and potent bioactive compound. |
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V1990 | Oridonin (NSC-250682) | 28957-04-2 | Oridonin (NSC-250682; Isodonol) is a novel, naturally occurring and cell-permeable diterpenoid extracted from Rabdosia rubescens with anticancer activity. |
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V4274 | Capivasertib | 1143532-39-1 | Capivasertib (formerly known as AZD5363), a novel pyrrolopyrimidine-derived compound, is a potent,orally bioavailablepan-AKTkinase inhibitor with potential anticancer activity. |
|
V9999998 | 危险化学品管理系统0000 | ||
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V0156 | Perifosine (KRX0401) | 157716-52-4 | Perifosine(also known as KRX-0401)is a potent, orally bioavailable and synthetic antitumor alkylphospholipid (APL) which acts as an Akt inhibitor and a PI3K inhibitor with potential anticancer activity. |
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V51338 | Kihadanin B | 73793-68-7 | citrus limonoidl inhibitor of Akt-FOXO1-PPARγ axis |
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V0158 | Ipatasertib (GDC0068; RG7440) | 1001264-89-6 | Ipatasertib (formerly also called GDC-0068; RG-7440) is a novel, potent, orally bioavailable, ATP-competitive and highly selective pan-Akt inhibitor targeting Akt1/2/3 with potential anticancer activity. |
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V33006 | Ipatasertib dihydrochloride (GDC-0068) | 1396257-94-5 | Ipatasertib dihydrochloride (formerly also called GDC-0068) is a novel, potent, orally bioavailable, ATP-competitive and highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM in cell-free assays, it showed 620-fold selectivity over PKA. |
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V0162 | Triciribine (API2; NSC 154020; VQD002) | 35943-35-2 | Triciribine (also known as API-2; NSC-154020; VQD-002), a cell-permeable tricyclic nucleoside molecule, is a potent DNA synthesis inhibitor with potential anticancer activity. |
|
V3839 | Uprosertib (GSK2141795) HCl | 1047635-80-2 | Uprosertib (formerly known as GSK2141795 and GSK795), an analog ofGSK2110183, is a potent, orally bioavailable andATP-competitive Akt inhibitor with IC50 values of 180 nM, 328 nM, and 38 nM for Akt1/Akt2/Akt3, respectively. |
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