Others 8

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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Others 8

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V4380	AVELUMAB	1537032-82-8	Avelumab (Anti-Human PD-L1, Human Antibody; MSB 0010718C; MSB0010718C; trade name Bavencio) is a fully human IgG1 anti-PD-L1 monoclonal antibody with potential antibody-dependent cell-mediated cytotoxicity.
V4244	AZD 4407	166882-70-8	AZD 4407 is a novel, potent and selective 5-lipoxygenaseinhibitor.
V4353	AZD-0284	2101291-07-8	AZD-0284 is a novel,potent, selective, inverse agonist of the nuclear receptorRORγ.
V4343	AZD-5991 S-ENANTIOMER	2143061-82-7	AZD-5991 S-enantiomer, theS-enantiomer of AZD-5991, is the less active enantiomer of AZD-5991.
V4236	AZD1979	1254035-84-1	AZD1979 is anovel and potent antagonist ofMelanin-concentrating hormone receptor 1(MCHr1) with anIC50of ~12 nM.
V4352	AZD2066	934282-55-0	AZD-2066 is a potent, selective, orally bioavailable and brain penetrant antagonist mGlu5 (metabotropic glutamate receptor 5) with IC50 in the nanomolar range for rat and human receptors, respectively.
V2115	AZD7687	1166827-44-6	AZD7687 is a novel, potent, selective,reversible and pyrazinecarboxamide-based inhibitor of diacylglycerol acyltransferase 1 (DGAT1) with an IC50 value of 80 nM for hDGAT1.
V4253	AZD9056	345304-65-6	AZD9056 is a novel, potent, selective, orally bioavailable antagonist of P2X7 receptor which is an adenosine triphosphate (ATP)-gated cation channel expressed on a variety of cell types believed to play a role in inflammation.
V2195	AZD9977	1850385-64-6	Balcinrenone (AZD9977) is a potent, selective, orally bioactive mineralocorticoid receptor (MR) modulator.
V4186	BAY-1316957	1613264-40-6	BAY-1316957 (BAY1316957) is a novel, highly potent, selective, and orally bioavailable antagonist of human prostaglandin E2 receptor subtype 4 (hEP4 receptor) with the potential to be usedfor the Treatment of Endometriosis.
V4170	BAY-320	1445830-50-1	BAY-320 is a novel and potent Bub1 inhibitor with anIC50of 680 nM for human Bub1 in the presence of 2 mM ATP.
V4189	BAY-Y 3118	151213-16-0	BAY-Y 3118 is novel and potent chlorofluoroquinolone derivative with antimicrobial activity againstHaemophilhs influenzae, Moraxela catarrhalis, Acinetobacter baumannii, Xanthomonas maltophiia, gram-positive cocci, and anaerobes; MICs for 50%o of the strains (MIC50s) and MIC90s are ≤0.015 and ≤0.015, ≤0.015 and ≤0.015, 0.03 and 2, 0.25 and 0.5, 0.06 and 1, and 0.12 and 0.25 μg/mL, respectively.
V2398	Benzamide HCl		Benzamide HCl is a potent FTO inhibitor with the potential to be used for treatingobesity, breast cancers, pancreatic cancer, and Alzheimers diseases.
V3955	BESIFOVIR	441785-26-8	Besifovir (formerly known as ANA-380; LB-80380; PMCDG dipivoxil; Korea Trade name: Besivo) is a reverse transcriptase inhibitor that has been approved in Korea to treat hepatitis B virus (HBV) infection.
V3956	BESIFOVIR MALEATE	1039623-01-2	Besifovir maleate (formerly known as ANA-380 maleate; LB-80380 maleate; PMCDG dipivoxil maleate; Korea Trade name: Besivo) is a reverse transcriptase inhibitor that has been approved in Korea to treat hepatitis B virus (HBV) infection.
V2112	BET-BAY 002	1588521-78-1	BET-BAY 002 is a novel and potentBET(Bromodomainand extra-terminal) inhibitor whichexhibits high efficacy in a multiple myeloma model.
V4373	BEVACIZUMAB	216974-75-3	Bevacizumab (trade nameAvastin; Anti-Human VEGF, Humanized Antibody) is a humanized monoclonal antibody which binds specifically to allVEGF-Aisoforms with high affinity.
V2121	BIIE-0246 (AR-H 053591)	246146-55-4	BIIE0246 (BIIE-0246) is a newly synthesized, potent and highly selective non-peptide neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 of 15 nM.
V0712	BioE-1115	1268863-35-9	BioE-1115 (BioE 1115) is a novel, potent and highly selectivePAS kinase (PASK)inhibitor with anIC50of ~4 nM, it is also a potentcasein kinase 2αinhibitor with anIC50of ~10 μM.
V2060	BMS 433796	935525-13-6	BMS 433796 is a novel and potentγ-secretaseinhibitor withAβlowering activity in a transgenic mouse model of Alzheimers disease.