A desirable monoclonal antibody, an effective cytotoxic drug, and a suitable linker make up antibody-drug conjugates (ADCs). A suitable linker between the antibody and the cytotoxic drug creates a clear bridge, enabling the antibody to precisely deliver the cytotoxic drug to tumor sites and deliver it only to tumor cells. In addition to conjugation, the linkers preserve the stability of ADCs during their preparation, storage, and systemic circulation phases.
The linkers found in the ADCs currently undergoing clinical evaluation are primarily divided into two groups: cleavable and noncleavable. Cleavable linkers rely on internal cellular mechanisms to release the toxin, such as cytoplasmic reduction, exposure to acidic conditions in the lysosome, or cleavage by particular cellular proteases. For the release of the cytotoxic molecule with noncleavable linkers, the antibody portion of the ADC must be broken down by proteolytic enzymes while retaining the linker and the amino acid by which it was attached to the antibody.
Based on knowledge of the internalization and breakdown of the antibody-target antigen complex and a comparison of the preclinical in vitro and in vivo activities of conjugates, the choice of linker depends on the target. Additionally, because each molecule has different chemical restrictions and frequently the drug structure lends itself to a particular linker, the choice of a linker is also influenced by the type of cytotoxin used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V54666 | alpha-Man-TEG-N3 | 246855-76-5 | alpha-Man-TEG-N3 is a dot chemical reagent containing an Azide (N3) moiety. |
|
V54576 | Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 | 2244602-35-3 | Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 (compound 5) is a branched linker that may be utilized to prepare antibody-drug conjugates (ADC). |
|
V52737 | Aminooxy-PEG2-BCN | 2253965-14-7 | Aminooxy-PEG2-BCN is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare ADCs. |
|
V77723 | Aminooxy-PEG2-bis-PEG3-BCN | Aminooxy-PEG2-bis-PEG3-BCN is a cleavable ADC (Antibody-drug conjugate) linker containing 5 PEG (polyethylene glycol) units, which may be utilized to prepare antibody-drug-conjugates/ADCss (ADC). | |
|
V77248 | APN-PEG36-tetrazine | APN-PEG36-tetrazine is an analog of APN-PEG4-tetrazine. | |
|
V54602 | Asn-Pro-Val-PABC-MMAE TFA | 2893871-67-3 | Asn-Pro-Val-PABC-MMAE TFA (compound 8) is an effective ADC linker for the preparation of Antibody-drug conjugates (ADC) [1]. |
|
V52879 | Azetidin-3-ol hydrochloride | 18621-18-6 | Azetidin-3-ol ( HCl) is a non-cleavable (non-degradable) ADC linker, used for the synthesis of active antibody conjugated molecules (ADCs). |
|
V52850 | Azetidine-3-carboxylic acid | 36476-78-5 | Azetidine-3-carboxylic acid is a non-cleavable (non-degradable) ADC linker, used for the synthesis of active antibody conjugated molecules (ADCs). |
|
V52645 | Azide-C2-Azide | 629-13-0 | Azide-C2-Azide is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare antibody-conjugated active molecules (ADC). |
|
V35053 | Azido Myristic Acid | 80667-36-3 | Azidomyristic acid is a reagent for click chemistry bearing an azide (N3) moiety. |
|
V52644 | Azido-C6-OH | 146292-90-2 | Azido-C6-OH is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare Antibody-drug conjugates (ADC). |
|
V54708 | Azido-PEG(4)-Val-Cit-PAB-PNP | 1869126-60-2 | Azido-PEG(4)-Val-Cit-PAB-PNP is an azide-bearing reagent for click chemistry. |
|
V54681 | Azido-PEG2-CH2COOH (CHA) | 2098500-94-6 | Azido-PEG2-CH2COOH (CHA) is an azide-modified PEG2 acid that can be used as a reagent for click chemistry. |
|
V53218 | Azidoacetic Acid (2-Azidoacetic acid) | 18523-48-3 | Azidoacetic Acid (2-Azidoacetic acid) (Compound 92-1) is a reagent for click chemistry bearing an azide (N3) moiety. |
|
V76120 | BCN-endo-PEG2-maleimide | 2675364-08-4 | BCN-endo-PEG2-maleimide is an ADC (Antibody-drug conjugate) Linker containing 4 PEG (polyethylene glycol) units. |
|
V76104 | BCN-endo-PEG4-NHS | 1702356-19-1 | BCN-endo-PEG4-NHS is an ADC (Antibody-drug conjugate) Linker containing 4 PEG (polyethylene glycol) units. |
|
V77920 | BCN-endo-PEG7-maleimide | BCN-endo-PEG7-maleimide is an ADC (Antibody-drug conjugate) Linker containing 7 PEG (polyethylene glycol) units. | |
|
V76128 | BCN-endo-PEG7-NH2 | 2143968-34-5 | BCN-endo-PEG7-NH2 is an ADC (Antibody-drug conjugate) Linker containing 7 PEG (polyethylene glycol) units. |
|
V76106 | BCN-exo-PEG2-maleimide | 2141976-22-7 | BCN-exo-PEG2-maleimide is an ADC (Antibody-drug conjugate) Linker containing 2 PEG (polyethylene glycol) units. |
|
V76113 | BCN-exo-PEG2-NH2 | 1357379-13-5 | BCN-exo-PEG2-NH2 is an ADC (Antibody-drug conjugate) Linker containing 2 PEG (polyethylene glycol) units. |
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