AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis.It is made up of three proteins (subunits), which when combined form a useful enzyme. The overall result of AMPK activation is stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. This is offset by inhibition of cholesterol, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis, and stimulation of hepatic fatty acid oxidation and ketogenesis. As a metabolic master switch, AMPK controls a number of intracellular processes, such as the uptake of glucose by cells, the -oxidation of fatty acids, and the GLUT4 and mitochondrial biogenesis.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V11178 | Buformin | 692-13-7 | Buformin (NSC-528218; 1-butylbiguanide) is an orally bioavailableAMPKactivator approved for use as anantidiabetic drug. |
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V16495 | Buformin hydrochloride | 1190-53-0 | Buformin hydrochloride(NSC-528218; NSC528218;1-butylbiguanide) is an orally availableAMPKactivator used as anantidiabetic drug belonging to the biguanide class. |
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V78668 | CB1R/AMPK modulator 1 | CB1R/AMPK modulator 1 (Compound 38-S) is an orally bioactive CB1R/AMPK modulator with a Ki of 0.81 nM and a CB1R IC50 of 3.9 nM. | |
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V50991 | Chamaejasmine | 69618-96-8 | Chamaejasmine is a biflavonoid that can be extracted from the root of Daphne wolfberry and has anti-tumor activity. |
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V52231 | COH-SR4 | 73439-19-7 | COH-SR4 is an AMPK activator. |
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V0251 | Dorsomorphin (BML275) | 866405-64-3 | Dorsomorphin(BML-275) is a reversible and selective AMPK (AMP-activated protein kinase) inhibitor with a Ki of 109 nM in cell-free assays, exhibiting little effects against closely related kinases such as ZAPK, SYK, PKCθ, PKA, and JAK3. |
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V0246 | Dorsomorphin 2HCl (BML275) | 1219168-18-9 | Dorsomorphin 2HCl (formerly BML-275 dihydrochloride) is a reversible and selective AMPK (AMP-activated protein kinase) inhibitor thatinhibits AMPK with a Ki of 109 nM in cell-free assays, exhibiting little inhibition against closely related kinases such as ZAPK, SYK, PKCθ, PKA, and JAK3. |
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V3967 | EX-229 | 1219739-36-2 | EX229 (EX-229; AMPK Activator 991), a benzimidazole analog, is a novel, potent and allosteric AMPK (AMP-activated protein kinase) activator with Kd values of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1 and α1β2γ1 in biolayer interferometry, respectively. |
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V21592 | Ginkgolide C (BN-52022) | 15291-76-6 | Ginkgolide C (BN-52022) is a naturally occuring product isolated from Ginko and a GABA-A receptor, α-1 GlyR, and PAF receptor antagonist. |
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V0249 | GSK621 | 1346607-05-3 | GSK621 is a novel, potent and selective activator of AMP-activated protein kinase (AMPK) with potential antitumor activity. |
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V0250 | HTH-01-015 | 1613724-42-7 | HTH-01-015 is a novel, potent and selective inhibitor of NUAK1( (NUAK family SnF1-like kinase-1)which can serve as useful chemical probes to delineate the biological roles of the NUAK kinases. |
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V80316 | HTH-02-006 | HTH-02-006 is a NUAK2 inhibitor (IC50=126nM). | |
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V51942 | IQZ23 | 2415643-79-5 | IQZ23 inhibits adipocyte differentiation by activating AMPK signaling pathway. |
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V55744 | Kazinol U | 1238116-48-7 | Kazinol U inhibits melanogenesis by inhibiting tyrosinase-related proteins through AMPK activation. |
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V40864 | Lixumistat (IM156) | 1422365-93-2 | IM156 (IM-156; IM 156;HL-156A;HL156A) is a metformin/biguanideanalogwith potential anticancer and neuroprotective activity. |
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V39112 | Lixumistat (IM156; HL156A; HL271) acetate | 1422365-94-3 | IM156 (also known as HL-156A; Lixumistat; HL-271) is a metforminderivative thac acts as a novel and highly potent AMPK activator that increases AMPK phosphorylation. |
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V13330 | Marein | 535-96-6 | Marein has neuro-protective (neuro-protection) effects by reducing damage to mitochondrial function and activation of the AMPK signaling pathway. |
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V55745 | MARK-IN-4 | 1990492-86-8 | MARK-IN-4 is a potent inhibitor of microtubule affinity-regulated kinase (MARK) with IC50 of 1 nM. |
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V76788 | MARK4 inhibitor 2 | MARK4 inhibitor 2 is an inhibitor (blocker/antagonist) of microtubule affinity-regulated kinase 4 (MARK4), with a Km value of 6.3×107 and IC50 of 0.82 μM. | |
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V4058 | MK-3903 | 1219737-12-8 | MK-3903 (MK3903) is a novel, potent and selectiveAMPK (AMP-activated protein kinase)activator with EC50 of 8 nM for α1 β1 γ1 subunit,leading to improved lipid metabolism and insulin sensitization in mice. |
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