AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis.It is made up of three proteins (subunits), which when combined form a useful enzyme. The overall result of AMPK activation is stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. This is offset by inhibition of cholesterol, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis, and stimulation of hepatic fatty acid oxidation and ketogenesis. As a metabolic master switch, AMPK controls a number of intracellular processes, such as the uptake of glucose by cells, the -oxidation of fatty acids, and the GLUT4 and mitochondrial biogenesis.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V4287 | MK8722 | 1394371-71-1 | MK-8722 (MK8722) is a novel, potent allostericpan-AMPK activator with anti-diabetic effects. |
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V12775 | Nilotinib HCl hydrate | 923288-90-8 | Nilotinib HCl hydrate (formerly also known asAMN-107, AMN107 HCl hydrate) is a potent, orally bioavailable aminopyrimidine-derivative Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells. |
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V33389 | O-304 | 1261289-04-6 | O-304 is a first-in-class, orally bioavailable pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. |
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V3110 | PF-06409577 | 1467057-23-3 | PF-06409577 (PF06409577) is a potent, selective, orally bioavailable, allosteric activator ofAMPKα1β1γ1 (5′ adenosine monophosphate-activated protein kinase) with the potential to be used for diabetic nephropathy. |
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V0247 | Phenformin HCl (ST50409947; D08352; W104144) | 834-28-6 | Phenformin HCl (ST-50409947; D-08352; W-104144), the hydrochloride salt of phenformin, was a marketed anti-diabetic drug ofthe biguanide class, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis. |
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V33400 | TMPA | 1258275-73-8 | TMPA is a high-affinity Nur77 antagonist, and binding to Nur77 results in the release and shuttling of LKB1 in the cytoplasm to activate AMPKα. |
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V0248 | WZ4003 | 1214265-58-3 | WZ4003 is a novel, potent and highly specific inhibitor of NUAK kinases. |
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V35098 | ZLN024 hydrochloride | 1883548-91-1 | ZLN024 HCl is an AMPK allosteric activator. |
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