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    PF-05175157
    PF-05175157

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4450
    CAS #: 1301214-47-0Purity ≥98%

    Description: PF-05175157 is a novel, potent and selective broad spectrum inhibitor of acetyl-CoA carboxylase (ACC) with IC50s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively. Acetyl-CoA carboxylase (ACC) inhibitors offer significant potential for the treatment of type 2 diabetes mellitus (T2DM), hepatic steatosis, and cancer. However, the identification of tool compounds suitable to test the hypothesis in human trials has been challenging. ACC inihibitors inhibit de novo lipogenesis and increase β-oxidation of long-chain fatty acids with potential for treatment of type 2 diabetes, hepatic steatosis, and cancer.

    References:  2014 Dec 26;57(24):10512-26. 


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    PF-05175157

    Name: PF 05175157
    CAS#: 1301214-47-0
    Chemical Formula: C23H27N5O2
    Exact Mass: 405.21648
    Molecular Weight: 405.5
    Elemental Analysis: C, 68.13; H, 6.71; N, 17.27; O, 7.89
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: PF-05175157; PF05175157; PF 05175157.
    IUPAC/Chemical Name: 1,4-Dihydro-1'-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one
    InChi Key: BDXXSFOJPYSYOC-UHFFFAOYSA-N
    InChi Code: InChI=1S/C23H27N5O2/c1-14(2)28-21-17(13-24-28)11-23(12-20(21)29)6-8-27(9-7-23)22(30)16-4-5-18-19(10-16)26-15(3)25-18/h4-5,10,13-14H,6-9,11-12H2,1-3H3,(H,25,26)
    SMILES Code: O=C1CC2(CCN(C(C3=CC=C4N=C(C)NC4=C3)=O)CC2)CC5=C1N(C(C)C)N=C5


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     PF-05175157


    Plasma concentrations of 1 and its alcohol metabolite 1m in beagle dogs following oral administration of 1 at 10 mg/kg.  2014 Dec 26;57(24):10512-26.

     PF-05175157


    Co-crystal structure of 1 bound in the CT-domain binding domain of ACC. Compound 1 was oriented in the channel by hydrogen bonds between the ketone and NH-Gly-B1958 and between the amide carbonyl and NH-Glu-B2026.  2014 Dec 26;57(24):10512-26.

     PF-05175157


    Plasma concentrations of 9 and its alcohol metabolite 9m in beagle dogs following oral administration of 9 at 3 mg/kg.  2014 Dec 26;57(24):10512-26.


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