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    Palovarotene
    Palovarotene

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V3434
    CAS #: 410528-02-8 Purity ≥98%

    Description: Palovarotene (formerly also known as RO-3300074 and R-667) is a novel, potent and highly selective retinoic acid receptor gamma (RAR-γ) agonist that is being investigated as a potential treatment for emphysema. Palovarotene effectively inhibited HO in injury-induced and genetic mouse models of the disease. It additionally prevents spontaneous HO, using a novel conditional-on knock-in mouse line carrying the human ACVR1(R206H) mutation for classic FOP. In addition, palovarotene restored long bone growth, maintained growth plate function, and protected growing mutant neonates when given to lactating mothers. Importantly, palovarotene maintained joint, limb, and body motion, providing clear evidence for its encompassing therapeutic potential as a treatment for FOP.

    References:  2018 Sep 18;7. pii: e40814;  2016 Sep;31(9):1666-75. 

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    Palovarotene

    Name: Palovarotene
    CAS#: 410528-02-8
    Chemical Formula: C27H30N2O2
    Exact Mass: 414.2307
    Molecular Weight: 414.549
    Elemental Analysis: C, 78.23; H, 7.29; N, 6.76; O, 7.72
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: RO-3300074; RO 3300074; RO3300074; R-667; R 667; R667
    Chemical Name: 4-((1E)-2-(5,5,8,8-Tetramethyl-3-(1H-pyrazol-1-ylmethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl)benzoic acid
    InChi Key: YTFHCXIPDIHOIA-DHZHZOJOSA-N
    InChi Code: InChI=1S/C27H30N2O2/c1-26(2)12-13-27(3,4)24-17-22(18-29-15-5-14-28-29)21(16-23(24)26)11-8-19-6-9-20(10-7-19)25(30)31/h5-11,14-17H,12-13,18H2,1-4H3,(H,30,31)/b11-8+
    SMILES Code: O=C(O)C1=CC=C(/C=C/C2=C(CN3N=CC=C3)C=C4C(C)(C)CCC(C)(C)C4=C2)C=C1


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    Palovarotene


    Injury-induced heterotopic ossification in Acvr1cR206H/+ mutant mice is inhibited by the RARγ agonist Palovarotene.

     Palovarotene


    Palovarotene preserves long bone growth and growth plate organization in Prrx1-R206H mice.  2016 Sep;31(9):1666-75.

     Palovarotene


    Chondrocyte proliferation and progression are altered in Prrx1-R206H growth plates.  2016 Sep;31(9):1666-75.


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