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Purity: ≥98%
Magnolol (also called Dehydrodichavicol and 5,5'-Diallyl-2,2'-biphenyldiol) is a novel, naturally occuring and bioactive lignin isolated from the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol is an isomer of honokiol (also known as sc-202653). Magnolol is an anxiolytic, anti-thrombotic and antibacterial. Also it is an inhibitor of nitric oxide (NO) and TNF-α production in LPS-activated macrophages by the suppression of inducible nitric oxide synthase(iNOS; NOS II) expression (IC50 = 16.8 μM). Magnolol is an activator of CB2 and CB1.
| ln Vitro |
Magnolol has EC50 values of 10.4 μM and 17.7 μM for RXRα and PPARγ, respectively, making it a dual coagulant. Magnolol (26.2 - 80 μM) has a dose-dependent binding behavior towards RXRαLBD and PPARγLBD, with Kd values of 45.7 μM and 1.67 μM, correspondingly. (1–20 μM) has no effect in modulating RXRE, but it causes PPRE to change in a dispensing manner [1]. In the presence of insulin, adipocyte secretion from 3T3-L1 preadipocytes and C3H10T1/2 pluripotent stem cells is enhanced by magnoliol (1, 3, 10 μM). Adipocyte secretory marker gene mRNA expression is increased by 10 μM of magnolil. In secretory 3T3-L1 adipocytes, magnoliol (1, 10 μM) increases both baseline and insulin-stimulated adipocyte secretion [2].
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| ln Vivo |
The severity of glucose fermentation sodium sulfate (DSS)-induced hot water sodium form in mice is markedly lessened by magnoliol (5–15 mg/kg, po). In mice exposed with DSS, magnoliol (10, 15 mg/kg, unintentional) inhibits myeloperoxidase activity and degenerative alterations in the underlying tissue. It also lowers the high levels of pro-inflammatory cytokines TNF-α, IL-1β, and IL-induced by DSS in the underlying tissue. 6. Renal color pathway anomalies can also be reversed and regulated by magnolizol (10 mg/kg, po) [3].
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| References |
[1]. Zhang H, et al. Molecular determinants of magnolol targeting both RXRα and PPARγ. PLoS One. 2011;6(11):e28253.
[2]. Choi SS, et al. Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. Life Sci. 2009 Jun 19;84(25-26):908-14. [3]. Zhao L, et al. Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. Molecules. 2017 Jul 20;22(7). pii: E1218 |
| Molecular Formula |
C18H18O2
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| Molecular Weight |
266.32
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| CAS # |
528-43-8
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| Related CAS # |
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| SMILES |
OC1=CC=C(CC=C)C=C1C2=CC(CC=C)=CC=C2O
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| InChi Key |
VVOAZFWZEDHOOU-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2
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| Chemical Name |
5,5-diallyl-[1,1-biphenyl]-2,2-diol
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| Synonyms |
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.39 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.39 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (9.39 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7549 mL | 18.7744 mL | 37.5488 mL | |
| 5 mM | 0.7510 mL | 3.7549 mL | 7.5098 mL | |
| 10 mM | 0.3755 mL | 1.8774 mL | 3.7549 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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