| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ln Vitro |
Compound 4i, ASM-IN-1, has no effect on HUVEC cell proliferation [1]. In HUVEC, LPS-stimulated IL-6 and TNF-α production is dose-dependently reduced by ASM-IN-1 (0, 1, 5 µM)[1]. ASM-IN-1 (5 µM) returns IL-6 mRNA to normal levels and decreases Ox-LDL-stimulated MCP-1 mRNA expression [1].
|
|---|---|
| ln Vivo |
In ICR mice, ASM-IN-1 (1 mg/kg intravenously; 10 mg/kg oral) demonstrates good pharmacokinetic features, with an oral bioavailability of 35.42% [1]. Through inhibition of ASM activity, ASM-IN-1 (6, 12, 40 mg/kg; intraperitoneal injection; twice daily for 8 weeks) has anti-atherosclerotic activity in mice [1].
|
| Cell Assay |
Cell Cytotoxicity Assay[1]
Cell Types: HUVECs Tested Concentrations: 0.5, 1, 5, 10, 20 µM Incubation Duration: 24, 48 h Experimental Results: demonstrated no affect on cell growth. |
| References |
| Exact Mass |
389.001
|
|---|---|
| CAS # |
2913151-46-7
|
| PubChem CID |
167312404
|
| Appearance |
White to off-white solid powder
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
6
|
| Rotatable Bond Count |
5
|
| Heavy Atom Count |
24
|
| Complexity |
412
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C1=CC(=CC=C1COC2=CC=C(C=C2)Br)C3=NOC(=N3)C(=O)NO
|
| InChi Key |
YYAPAXZETRKZHT-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C16H12BrN3O4/c17-12-5-7-13(8-6-12)23-9-10-1-3-11(4-2-10)14-18-16(24-20-14)15(21)19-22/h1-8,22H,9H2,(H,19,21)
|
| Chemical Name |
3-[4-[(4-bromophenoxy)methyl]phenyl]-N-hydroxy-1,2,4-oxadiazole-5-carboxamide
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: ~60 mg/mL (~153.8 mM; with ultrasonication)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 3 mg/mL (7.69 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (30.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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