Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. The reducing equivalents NADH and FADH2, which transfer their electrons to the electron transport chain, are produced by these carbon fuels by feeding into the TCA cycle in the mitochondrial matrix. Complex organelles called mitochondria are crucial for many aspects of cellular function, including metabolism, immune control, and cell death.Calcium buffering, lipid flux, and intracellular signaling are just a few of the many cellular processes and molecular interactions that mitochondria actively participate in. It is becoming more widely acknowledged that mitochondrial dysfunction is a defining feature of many diseases, including cancer, cardiovascular, and neurodegenerative conditions. Mitochondrial metabolism influences processes like the epithelial-to-mesenchymal transition, which is a key factor in the progression of tumors. The epigenetic landscape is altered by mitochondrial metabolism and the oncometabolites that result to change the aggressiveness characteristics of cancer cells. Regarding the survival of tumors in response to treatment, changes in mitochondrial metabolism are important.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73212 | Magmas-IN-1 | 1251957-89-7 | Magmas-IN-1 (compound 9) is a small molecule Magmas inhibitor (SMMI). |
|
V73203 | Malonyl Coenzyme A lithium | 108347-84-8 | Malonyl Coenzyme A lithium is an inhibitor (blocker/antagonist) of carnitine palmitoyltransferase 1 (CPT1). |
|
V2300 | MCU-i4 | 371924-24-2 | MCU-i4 is a negative modulator ofof the MCU (mitochondrial calcium uniporter), acting by inhibitingIP3-dependent mitochondrial Ca2+-uptake and maintaining the gatekeeping role of their target. |
|
V73205 | Menadiol (Dihydrovitamin K3) | 481-85-6 | Menadiol (Dihydrovitamin K3) is a menaquinone analog and an electron donor for reverse oxidative phosphorylation in submitochondrial granules. |
|
V73199 | Mitochondrial fusion promoter M1 | 219315-22-7 | Mitochondrial fusion promoter M1 is a regulator of mitochondrial dynamics. |
|
V76764 | Mitochondrial respiration-IN-1 hydrobromide | Mitochondrial respiration-IN-1 HBr (compound 49) is a potent mitochondrial (mitochondrial) inhibitor (IC50=8.8 mg/mL), which can significantly reduce platelet mitochondrial respiration. | |
|
V80779 | Mitochondrial respiration-IN-3 | Mitochondrial respiration-IN-3 is a fluorine analogue of Dalfopristin. | |
|
V73217 | MitoTEMPO hydrate | 1569257-94-8 | Mito TEMPO is a mitochondria-targeted antioxidant with superoxide and alkyl radical scavenging properties. |
|
V73198 | MPP+ iodide | 36913-39-0 | MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes PD/Parkinson's disease symptoms in animal models by selectively destroying dopaminergic neurons in the substantia nigra. |
|
V9679 | MSDC-0602 | 1133819-87-0 | MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes (metabolic modulator). |
|
V73206 | Ninerafaxstat (IMB-1018972; IMB-101) | 2254741-41-6 | Ninerafaxstat (IMB-1018972) is a cardiac mitochondrion-stimulating agent that increases myocardial metabolic efficiency by reducing fatty acid oxidation (inhibiting 3-ketoacyl-CoA thiolase) and shifting substrate utilization toward glucose. |
|
V73209 | Ninerafaxstat trihydrochloride (MB-1018972 trihydrochloride; IMB-101 trihydrochloride) | 2311824-72-1 | Ninerafaxstat (IMB-1018972) tri HCl is a cardiac mitochondrial agent that increases myocardial metabolic efficiency by reducing fatty acid oxidation (inhibiting 3-ketoacyl-CoA thiolase) and shifting substrate utilization toward glucose. |
|
V0159 | NSC-102533 | 1150-59-0 | Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. |
|
V81061 | PDK-IN-2 | PDK-IN-2 (Compound 1F) is a PDK inhibitor (IC50= 68 nM). | |
|
V79178 | Perhexiline-d11 maleate (Perhexiline-d11 maleate) | Perhexiline-d11 (maleate) is the deuterated form of Perhexiline maleate. | |
|
V81152 | PK-10 | PK-10 is a synergistic antibacterial agent of Fluconazole and has strong antifungal activity against a variety of Fluconazole-resistant Candida albicans strains. | |
|
V73210 | SCAL-255 | 2798953-61-2 | SCAL-255 is a potent mitochondrial complex I (CI) inhibitor (antagonist) with IC50 of 1.14 μM. |
|
V73216 | SCAL-266 | 2798953-78-1 | SCAL-266 is a potent mitochondrial complex I (CI) inhibitor (antagonist) with IC50 of 0.83 μM. |
|
V73211 | Senecionine acetate (O-Acetylsenecionine) | 126642-77-1 | Senecionine acetate (O-Acetylsenecionine) is a pyrrolidine core alkaloid. |
|
V73202 | SH-BC-893 | 1841409-92-4 | SH-BC-893 is an antitumor sphingolipid analog with oral activity. |
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