The ER-membrane protein Stimulator of Interferon Genes (STING) can be activated by the 2'3'-cGAMP produced by the enzyme Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS) in response to the binding of double-stranded DNA. To protect against microbial infection, it activates inflammatory cytokine and interferon (IFN) responses.
STING is an important cytosolic receptor for small nucleotides that is essential for both antiviral and anticancer immunity. The STING signaling pathway triggers anti-tumor immune responses and serves as a vital link between innate and adaptive immunity. In numerous studies for immunogenic tumor clearance, antiviral therapies, and vaccine adjuvants, STING agonists like endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP) have been used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V74332 | STING agonist-13 | 2816929-48-1 | STING agonist-13 is a STING agonist that performs cancer immunity through STING-mediated immune activation. |
|
V74328 | STING agonist-17 | 2816929-47-0 | STING agonist-17 (compound 4a) is a potent STING agonist/activator with IC50 of 0.062 nM. |
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V74313 | STING agonist-22 | 2408723-12-4 | STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. |
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V51054 | STING agonist-23 | 2361570-16-1 | STING agonist-23 (CF502) is a novel non-nucleotide-based STING agonist. |
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V51055 | STING agonist-24 | 2408722-91-6 | STING agonist-24 (CF504) is a novel non-nucleotide-based STING agonist. |
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V51053 | STING agonist-25 | 2408723-10-2 | STING agonist-25 (CF505) is a novel non-nucleotide-based STING agonist. |
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V51057 | STING agonist-26 | 2868261-48-5 | STING agonist-26 (CF508) is a novel non-nucleotide-based STING agonist. |
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V74320 | STING agonist-27 | 2868261-45-2 | STING agonist-27 (CF509) is a non-nucleotide small molecule STING agonist. |
|
V51056 | STING agonist-28 | 2868261-50-9 | STING agonist-28 (CF510) is a novel non-nucleotide-based STING agonist. |
|
V74330 | STING agonist-29 | 2868261-51-0 | STING agonist-29 (CF511) is a non-nucleotide small molecule STING agonist. |
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V31647 | STING agonist-3 | 2138299-29-1 | STING agonist-3, compound 3, is a selective and non-nucleotide small-molecule STING agonist, which has durable anti-tumor effect and tremendous potential to improve treatment of cancer. |
|
V76475 | STING agonist-3 trihydrochloride | STING agonist-3 tri HCl, found in patent WO2017175147A1 (Example 10), is a selective and non-nucleotide small molecule STING agonist/activator with pEC50 and pIC50 of 7.5 and 9.5 respectively. | |
|
V74319 | STING agonist-31 | 2719001-44-0 | STING agonist-31 is a STING agonist/activator with EC50s of 0.24 and 39.51 μM for h-STING and m-STING. |
|
V74323 | STING agonist-34 | 2913152-30-2 | STING agonist-34 (Compound 12L) is a potent STING agonist/activator with IC50 of 1.15 μM and EC50 of 0.38 μM in THP1 cells. |
|
V31644 | STING agonist-4 | 2138300-40-8 | STING agonist-4 (diABZI STING agonist-2) is a novel and potent agonist of stimulator of Interferon Genes (STING) receptor with an apparent inhibitory constant (IC50) of 20 nM. |
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V74315 | STING agonist-7 | 2767442-46-4 | STING agonist-7 is a non-nucleotide STING agonist that selectively binds mouse STING but not human STING. |
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V76474 | STING agonist-8 dihydrochloride | STING agonist-8 diHCl (5-AB) is a potent STING agonist with EC50 of 27 nM in THP1-Dual KI-hSTING-R232 cells. | |
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V2457 | STING inhbitor 1 | 727699-84-5 | SN-001 is a STING inhibitor (antagonist) with IC50 of 3.82 μM. |
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V2458 | STING inhibitor 2 | 2249435-90-1 | STING inhbitor 2 ( SN-011; SN011) is a novel and potent inhibitor of STING with potential anti-inflammatory activity. |
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V74322 | STING modulator-3 | 2839639-94-8 | STING modulator-3 is a STING inhibitor. |
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