Size | Price | Stock | Qty |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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ln Vitro |
Targeting the human STING's cyclic dinucleotide binding pocket is SN-001 [1]. In a dose-dependent manner, SN-001 (5–20 μM; 6 hours) significantly reduces the induction of Ifnb mRNA in L929 cells [1]. Cytosolic DNA-induced STING signaling is inhibited by SN-001 (10 μM; 3 hours) [1].
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Cell Assay |
Western Blot Analysis[1]
Cell Types: L929 Cell Tested Concentrations: 10 μM Incubation Duration: 3 hrs (hours) Experimental Results: Cytoplasmic DNA-induced reduction in STING, TBK1, IRF3, IκBα and p65 phosphorylation and nuclear translocation of IRF3 and p65. |
References |
[1]. Hong Z, et al. STING inhibitors target the cyclic dinucleotide binding pocket. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2105465118.
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Molecular Formula |
C26H21FN2O4S
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Molecular Weight |
476.5193
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CAS # |
727699-84-5
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SMILES |
S(C1C([H])=C([H])C(=C([H])C=1[H])F)(N([H])C1=C(C([H])=C([H])C(=C1[H])N([H])C(C1C([H])=C([H])C(=C([H])C=1[H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O)OC([H])([H])[H])(=O)=O
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~250 mg/mL (~524.64 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.36 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.0985 mL | 10.4927 mL | 20.9855 mL | |
5 mM | 0.4197 mL | 2.0985 mL | 4.1971 mL | |
10 mM | 0.2099 mL | 1.0493 mL | 2.0985 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.