The ER-membrane protein Stimulator of Interferon Genes (STING) can be activated by the 2'3'-cGAMP produced by the enzyme Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS) in response to the binding of double-stranded DNA. To protect against microbial infection, it activates inflammatory cytokine and interferon (IFN) responses.
STING is an important cytosolic receptor for small nucleotides that is essential for both antiviral and anticancer immunity. The STING signaling pathway triggers anti-tumor immune responses and serves as a vital link between innate and adaptive immunity. In numerous studies for immunogenic tumor clearance, antiviral therapies, and vaccine adjuvants, STING agonists like endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP) have been used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V74317 | Dazostinag (TAK-676 free base) | 2553413-86-6 | Dazostinag (TAK-676 free base) is an agonist of stimulator of interferon genes (STING) protein and has anti-tumor activity. |
|
V31646 | diABZI STING agonist-1 | 2138299-33-7 | diABZI STING agonist-1 is a novel, potent and selective STING (stimulator of interferon genes) receptor agonist, with an EC50s of 130 nM for human PBMCs. |
|
V31645 | diABZI STING agonist-1 trihydrochloride | 2138299-34-8 | diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with an EC50s of 130 for human PBMCs. |
|
V74310 | diABZI-C2-NH2 | 2137975-93-8 | diABZI-C2-NH2 is an active analog containing primary amine function and a STING agonist. |
|
V74311 | E7766 diammonium salt | 2242635-03-4 | E7766 diammonium salt is a macrocyclic bridged STING agonist/activator with a Kd of 40 nM. |
|
V79211 | F-CRI1 | F-CRI1 is a potent STING agonist/activator with a Kd of 40.62 nM. | |
|
V21450 | G10 | 702662-50-8 | STING agonist-1 (G10) is a human-specific STING agonist that elicits anti-viral effect against emerging alphaviruses. |
|
V22028 | H 151 (H-151) | 941987-60-6 | H151 (H-151) isa potent,selective andirreversible STING antagonist/inhibitor with the potential to be used for autoimmune diseases such as arthritis and other inflammatory conditions. |
|
V76903 | IACS-8803 diammonium | IACS-8803 diammonium is a potent cyclic dinucleotide STING agonist with potent systemic anti-tumor effects. | |
|
V74309 | IACS-8803 disodium | 2243079-36-7 | IACS-8803 disodium is a potent cyclic dinucleotide STING agonist with potent systemic anti-tumor effects. |
|
V80542 | LB244 | LB244 is a homologue of BB-Cl-amidine, which is an orally bioactive STING inhibitor (EC50=0.8 μM) and may be utilized to inhibit STING-dependent inflammatory diseases. | |
|
V19990 | m-Cl-CCP (CCCP) | 555-60-2 | m-Cl-CCP [555-60-2] is a protonophore (h+ ionophore) and uncoupler of oxidative phosphorylation in mitochondria, inhibiting secretion of hepatic lipase and partially inhibiting the ph gradient-activated cl- uptake and cl-/cl- exchange activities in brush-border membrane vesicles |
|
V2470 | MSA-2 | 129425-81-6 | MSA 2 (MSA2;MSA-2) is a novel, orally bioactive and potent non-nucleotide agonist of stimulator of interferon genes (STING) with potential antitumor activity. |
|
V74312 | MSA-2 dimer | 2377881-92-8 | MSA-2 dimer is a selective and orally bioactive non-nucleotide STING agonist (Kd=145 μM) with long-term anti-tumor and immunogenic activity. |
|
V78866 | NVS-STG2 | NVS-STG2 is a molecular glue targeting STING and can activate STING-mediated immune signaling. | |
|
V79086 | SAP-04 | SAP-04 is a potent orally bioactive STING agonist. | |
|
V74314 | SN-008 | 2249106-01-0 | SN-008 is a low activity analog of SN-011 and can be used as a negative control (NC). |
|
V41902 | SP-23 | 2762552-74-7 | SP-23 (SP23) is a novel, first-in-class and potent STING-targeting PROTAC degrader based on C-170 (STING inhibitor) with anti-inflammatory effects. |
|
V51740 | SR-717 | 2375420-34-9 | SR-717 free acid is a non-nuclear STING-like agonist/activator with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cells, respectively. |
|
V2205 | SR-717 lithium | 2375421-09-1 | SR-717 lithium is a novel, potent and non-nucleotide STING (stimulator of interferon genes) agonist with anticancer activities. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
